crovalimab   Click here for help

GtoPdb Ligand ID: 12790

Synonyms: RG-6107 | RG6107 | SKY59
Immunopharmacology Ligand
Compound class: Antibody
Comment: Crovalimab (SKY59/RG6107) is a long-acting anti-C5 recycling monoclonal antibody [1-2]. The antibody is engineered to bind C5 in a pH-dependent manner. It binds strongly to C5 in the plasma, but in the acidic conditions within the endosome the antibody-C5 mmune complex dissociates; the free antibody is re-cycled and the C5 is trafficked to the lysosome for degradation. Crovalimab is proposed as a treatment for complement-mediated disorders such as paroxysmal nocturnal hemoglobinuria (PNH) and Lupus nephritis.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10882 crovalimab
Synonyms Click here for help
RG-6107 | RG6107 | SKY59
Database Links Click here for help
GtoPdb PubChem SID 483123338
Search PubMed clinical trials crovalimab
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