ChEMBL ligand: CHEMBL82298 (Immethridine)
H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] There should be some charts here, you may need to enable JavaScript!
H4 receptor/Histamine H4 receptor in Human [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL	Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells	B	9.07	pKi	0.85	nM	Ki	J Med Chem (2004) 47: 2414-2417 [PMID:15115383]
GtoPdb	-	-	9.1	pKi	-	-	-	J Med Chem (2004) 47: 2414-7 [PMID:15115383]
ChEMBL	Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells	B	9.1	pKi	0.79	nM	Ki	J Med Chem (2008) 51: 2944-2953 [PMID:18433114]
ChEMBL	Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells	B	9.1	pKi	0.79	nM	Ki	Bioorg Med Chem Lett (2010) 20: 7191-7199 [PMID:21044842]
ChEMBL	Displacement of [3H](R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation counting	B	9.11	pKi	0.77	nM	Ki	J Med Chem (2010) 53: 6445-6456 [PMID:20690643]
ChEMBL	Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	F	8.96	pEC50	1.1	nM	EC50	J Med Chem (2010) 53: 6445-6456 [PMID:20690643]
ChEMBL	Agonist activity at human histamine H3 receptor assessed as beta galactosidase activity	F	9.7	pEC50	0.2	nM	EC50	J Med Chem (2008) 51: 2944-2953 [PMID:18433114]
ChEMBL	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H3 receptor	B	9.74	pEC50	0.18	nM	EC50	J Med Chem (2004) 47: 2414-2417 [PMID:15115383]
ChEMBL	Agonist activity at human histamine H3 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	F	9.8	pEC50	0.16	nM	EC50	Bioorg Med Chem Lett (2010) 20: 7191-7199 [PMID:21044842]
H4 receptor/Histamine H4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
ChEMBL	Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2	B	6.6	pKi	251.19	nM	Ki	Bioorg Med Chem Lett (2010) 20: 7191-7199 [PMID:21044842]
ChEMBL	Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells	B	6.61	pKi	245.47	nM	Ki	J Med Chem (2004) 47: 2414-2417 [PMID:15115383]
ChEMBL	Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay	F	6	pEC50	1000	nM	EC50	Bioorg Med Chem Lett (2010) 20: 7191-7199 [PMID:21044842]
ChEMBL	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	B	6.04	pEC50	912.01	nM	EC50	J Med Chem (2004) 47: 2414-2417 [PMID:15115383]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]