amylin   Click here for help

GtoPdb Ligand ID: 687

Abbreviated name: AMY
Comment: Amylin acts as an appetite suppressor. Novo Nordisk have a long-acting amylin mimetic (AM833, NNC0174-0833) in clinical trials with and without semaglutide. AM833 is intended as a treatment for obesity. In the trials it is administered subcutaneously, once-weekly. Preliminary (and as yet unpublished) results from a Phase 2 trial as monotherapy demonstrated weight loss of 10.8% at week 26, meeting the study's primary endpoint (Novo Nordisk press release 18 Jun 2020).
Species: Human
Click here for help
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IAPP islet amyloid polypeptide Human pre-pro-IAPP DAP, IAP
Database Links Click here for help
Specialist databases
GPCRdb Ligand amylin
Other databases
CAS Registry No. 122384-88-7 (Hs)
Ensembl Gene ENSG00000121351 (Hs)
Entrez Gene 3375 (Hs)
GtoPdb PubChem SID 135651612
Human Protein Atlas ENSG00000121351 (Hs)
UniProtKB P10997 (Hs)
Wikipedia Amylin