adapalene [Ligand Id: 5429] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1265 (Differin, CD 271, CD-271, Adapalene)
  • glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
There should be some charts here, you may need to enable JavaScript!
  • Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
There should be some charts here, you may need to enable JavaScript!
  • Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
ChEMBL Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-electrode voltage clamp assay B 5.89 pEC50 1300 nM EC50 J. Med. Chem. (2015) 58: 2958-2966 [PMID:25790278]
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis B 5.29 pIC50 5100 nM IC50 Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis B 5.68 pIC50 2100 nM IC50 Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809P61604]
ChEMBL Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis B 5.64 pIC50 2300 nM IC50 Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL Binding affinity towards Retinoic acid receptor alpha B 5.96 pKi 1100 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 2289-2294
ChEMBL Binding affinity to retinoic acid receptor alpha using [3H]CD 367 as radioligand B 5.96 pKi 1100 nM Ki J. Med. Chem. (1995) 38: 4993-5006 [PMID:8544175]
GtoPdb Binding affinity to RARα using [3H]CD 367 as radioligand. - 5.96 pKi 1100 nM Ki J Med Chem (1995) 38: 4993-5006 [PMID:8544175]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL Binding affinity towards Retinoic acid receptor beta B 7.47 pKi 34 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 2289-2294
ChEMBL Binding affinity to retinoic acid receptor beta using [3H]CD 367 as radioligand B 7.47 pKi 34 nM Ki J. Med. Chem. (1995) 38: 4993-5006 [PMID:8544175]
GtoPdb Binding affinity to RARβ using [3H]CD 367 as radioligand. - 7.47 pKi 34 nM Ki J Med Chem (1995) 38: 4993-5006 [PMID:8544175]
ChEMBL Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs by luciferase reporter gene assay B 8.7 pEC50 2 nM EC50 Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL Binding affinity towards Retinoic acid receptor gamma B 6.89 pKi 130 nM Ki Bioorg. Med. Chem. Lett. (1997) 7: 2289-2294
ChEMBL Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radioligand B 6.89 pKi 130 nM Ki J. Med. Chem. (1995) 38: 4993-5006 [PMID:8544175]
GtoPdb Binding affinity to RARγ using [3H]CD 367 as radioligand. - 6.89 pKi 130 nM Ki J Med Chem (1995) 38: 4993-5006 [PMID:8544175]
ChEMBL Agonist activity at GAL4 DNA-binding domain-tagged RARgamma (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs by luciferase reporter gene assay B 8.51 pEC50 3.1 nM EC50 Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]