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ChEMBL ligand: CHEMBL76232 (E620, Glutamic acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Glutamate racemase in Lactobacillus fermentum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3353] [UniProtKB: Q03469] | ||||||||
ChEMBL | Inhibition towards glutamate racemase from Lactobacillus fermenti was determined and expressed as KI | B | 4.25 | pKi | 56000 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2265-2270 |
Glutamate racemase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6078] [UniProtKB: P56068] | ||||||||
ChEMBL | Inhibition of Helicobacter pylori glutamate racemase | B | 5.24 | pKi | 5800 | nM | Ki | Nature (2007) 447: 817-822 [PMID:17568739] |
GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444, 445, 446, 447] [UniProtKB: P19490, P19491, P19492, P19493] | ||||||||
ChEMBL | Tested for inhibition of Specific DL-[H]Ionotropic glutamate receptor AMPA binding to rat brain membranes | B | 4 | pIC50 | ~100000 | nM | IC50 | J Med Chem (1983) 26: 901-903 [PMID:6133955] |
GluK1/GluK2/GluK3/GluK4/GluK5/Glutamate receptor ionotropic, kainate in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094119] [GtoPdb: 450, 451, 452, 453, 454] [UniProtKB: P22756, P42260, P42264, Q01812, Q63273] | ||||||||
ChEMBL | In vitro binding affinity against synaptic membrane from rat brain using [3H]KAIN as the radioligand | B | 4.11 | pIC50 | 78000 | nM | IC50 | J Med Chem (1989) 32: 2254-2260 [PMID:2552114] |
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 1 | B | 5 | pEC50 | 10000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 2 | B | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 3 | B | 5.05 | pEC50 | 9000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
ChEMBL | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active | F | 4 | pEC50 | <100000 | nM | EC50 | J Med Chem (2005) 48: 2534-2547 [PMID:15801843] |
ChEMBL | Effect on Metabotropic glutamate receptor 4 | B | 4.92 | pEC50 | 12000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 5 | B | 5.36 | pEC50 | 4400 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 6 | B | 4.7 | pEC50 | 20000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]