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ChEMBL ligand: CHEMBL76232 (E620, Glutamic acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Glutamate racemase in Lactobacillus fermentum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3353] [UniProtKB: Q03469] | ||||||||
ChEMBL | Inhibition towards glutamate racemase from Lactobacillus fermenti was determined and expressed as KI | B | 4.25 | pKi | 56000 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2265-2270 |
Glutamate racemase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6078] [UniProtKB: P56068] | ||||||||
ChEMBL | Inhibition of Helicobacter pylori glutamate racemase | B | 5.24 | pKi | 5800 | nM | Ki | Nature (2007) 447: 817-822 [PMID:17568739] |
GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444, 445, 446, 447] [UniProtKB: P19490, P19491, P19492, P19493] | ||||||||
ChEMBL | Tested for inhibition of Specific DL-[H]Ionotropic glutamate receptor AMPA binding to rat brain membranes | B | 4 | pIC50 | ~100000 | nM | IC50 | J Med Chem (1983) 26: 901-903 [PMID:6133955] |
GluK1/GluK2/GluK3/GluK4/GluK5/Glutamate receptor ionotropic, kainate in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094119] [GtoPdb: 450, 451, 452, 453, 454] [UniProtKB: P22756, P42260, P42264, Q01812, Q63273] | ||||||||
ChEMBL | In vitro binding affinity against synaptic membrane from rat brain using [3H]KAIN as the radioligand | B | 4.11 | pIC50 | 78000 | nM | IC50 | J Med Chem (1989) 32: 2254-2260 [PMID:2552114] |
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 1 | B | 5 | pEC50 | 10000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 2 | B | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 3 | B | 5.05 | pEC50 | 9000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
ChEMBL | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active | F | 4 | pEC50 | <100000 | nM | EC50 | J Med Chem (2005) 48: 2534-2547 [PMID:15801843] |
ChEMBL | Effect on Metabotropic glutamate receptor 4 | B | 4.92 | pEC50 | 12000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 5 | B | 5.36 | pEC50 | 4400 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349] | ||||||||
ChEMBL | Effect on Metabotropic glutamate receptor 6 | B | 4.7 | pEC50 | 20000 | nM | EC50 | J Med Chem (1997) 40: 3700-3705 [PMID:9357538] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]