AZD6703 [Ligand Id: 7687] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2031465 (AZ12012199, AZ-12012199, Azd6703, Azd 6703, Azd-6703, AZD-6703)
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-3883 [PMID:22608965]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha in human PBMC assessed as increase in LPS-induced ATF2 phosphorylation stimulated with LPS for 35 mins followed by compound treatment measured after 1 hr in presence of ATP by Western blot analysis B 7.3 pIC50 50.12 nM IC50 Bioorg Med Chem Lett (2020) 30: 127412-127412 [PMID:32717614]
ChEMBL Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood B 7.56 pIC50 27.54 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood B 7.57 pIC50 27 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha MAPK (unknown origin) B 7.7 pIC50 19.95 nM IC50 Bioorg Med Chem Lett (2020) 30: 127412-127412 [PMID:32717614]
ChEMBL Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human whole blood IC50 B 7.76 pIC50 17.38 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha kinase B 7.8 pIC50 16 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-3883 [PMID:22608965]
ChEMBL Inhibition of p38alpha kinase B 7.8 pIC50 15.85 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-3883 [PMID:22608965]
GtoPdb - - 7.81 pIC50 15.58 nM IC50 Bioorg Med Chem Lett (2012) 22: 3879-83 [PMID:22608965]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]