BMS-214662 [Ligand Id: 8026] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL351706 (Bms 214662, Bms-214662, BMS-214662) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| farnesyltransferase, CAAX box, subunit alpha/Geranylgeranyl transferase type I in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354, P53609] | ||||||||
| ChEMBL | Inhibition of geranylgeranyl transferase (GGT1) using K-Ras as substrate | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2000) 43: 3587-3595 [PMID:11020273] |
| ChEMBL | Inhibition of geranylgeranyl transferase (GGT1) using Ras-CVLL as substrate | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2000) 43: 3587-3595 [PMID:11020273] |
| farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356] | ||||||||
| ChEMBL | Inhibition of farnesyltransferase (unknown origin) assessed as KRAS farnesylation | B | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (2013) 56: 5219-5230 [PMID:23566315] |
| ChEMBL | Inhibitory concentration against farnesyltransferase was determined | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2004) 47: 1869-1878 [PMID:15055985] |
| ChEMBL | Inhibition of human FTase | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6896-6902 [PMID:23036952] |
| ChEMBL | Inhibition of human recombinant FTase | B | 8.87 | pIC50 | 1.35 | nM | IC50 | J Med Chem (2018) 61: 3239-3252 [PMID:28505447] |
| ChEMBL | Inhibition of purified recombinant human farnesyltransferase (FT) | B | 8.87 | pIC50 | 1.35 | nM | IC50 | J Med Chem (2000) 43: 3587-3595 [PMID:11020273] |
| GtoPdb | - | - | 8.87 | pIC50 | 1.35 | nM | IC50 | J Med Chem (2000) 43: 3587-95 [PMID:11020273] |
| ChEMBL | Inhibition of farnesyltransferase | B | 8.89 | pIC50 | 1.3 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 767-771 [PMID:14741286] |
| ChEMBL | Inhibition of farnesyltransferase (unknown origin) assessed as HRAS farnesylation | B | 8.89 | pIC50 | 1.3 | nM | IC50 | J Med Chem (2013) 56: 5219-5230 [PMID:23566315] |
| ChEMBL | Inhibition of Farnesyltransferase | B | 9.15 | pIC50 | 0.7 | nM | IC50 | J Med Chem (2004) 47: 612-626 [PMID:14736242] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
