BMS-214662 [Ligand Id: 8026] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL351706 (Bms-214662, BMS-214662, Bms 214662)
  • farnesyltransferase, CAAX box, alpha/Geranylgeranyl transferase type I in Human [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354P53609]
There should be some charts here, you may need to enable JavaScript!
  • farnesyltransferase, CAAX box, alpha/farnesyltransferase, CAAX box, beta/Protein farnesyltransferase in Human [ChEMBL: CHEMBL2094108] [GtoPdb: 28252826] [UniProtKB: P49354P49356]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyltransferase, CAAX box, alpha/Geranylgeranyl transferase type I in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354P53609]
ChEMBL Inhibition of geranylgeranyl transferase (GGT1) using K-Ras as substrate B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (2000) 43: 3587-3595 [PMID:11020273]
ChEMBL Inhibition of geranylgeranyl transferase (GGT1) using Ras-CVLL as substrate B 5.89 pIC50 1300 nM IC50 J. Med. Chem. (2000) 43: 3587-3595 [PMID:11020273]
farnesyltransferase, CAAX box, alpha/farnesyltransferase, CAAX box, beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 28252826] [UniProtKB: P49354P49356]
ChEMBL Inhibition of farnesyltransferase (unknown origin) assessed as KRAS farnesylation B 8.08 pIC50 8.4 nM IC50 J. Med. Chem. (2013) 56: 5219-5230 [PMID:23566315]
ChEMBL Inhibitory concentration against farnesyltransferase was determined B 8.85 pIC50 1.4 nM IC50 J. Med. Chem. (2004) 47: 1869-1878 [PMID:15055985]
ChEMBL Inhibition of human FTase B 8.85 pIC50 1.4 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6896-6902 [PMID:23036952]
ChEMBL Inhibition of human recombinant FTase B 8.87 pIC50 1.35 nM IC50 J Med Chem (2018) 61: 3239-3252 [PMID:28505447]
ChEMBL Inhibition of purified recombinant human farnesyltransferase (FT) B 8.87 pIC50 1.35 nM IC50 J. Med. Chem. (2000) 43: 3587-3595 [PMID:11020273]
GtoPdb - - 8.87 pIC50 1.35 nM IC50 J Med Chem (2000) 43: 3587-95 [PMID:11020273]
ChEMBL Inhibition of farnesyltransferase B 8.89 pIC50 1.3 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 767-771 [PMID:14741286]
ChEMBL Inhibition of farnesyltransferase (unknown origin) assessed as HRAS farnesylation B 8.89 pIC50 1.3 nM IC50 J. Med. Chem. (2013) 56: 5219-5230 [PMID:23566315]
ChEMBL Inhibition of Farnesyltransferase B 9.15 pIC50 0.7 nM IC50 J. Med. Chem. (2004) 47: 612-626 [PMID:14736242]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]