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HRAS

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Target not currently curated in GtoImmuPdb

Target id: 2822

Nomenclature: HRAS

Family: RAS subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 189 11p15.5 HRAS HRas proto-oncogene, GTPase
Mouse - 189 7 86.48 cM Hras Harvey rat sarcoma virus oncogene
Rat - 189 1q41 Hras HRas proto-oncogene, GTPase
Gene and Protein Information Comments
Three isoforms have been identified for human HRAS. Isoforms 1 and 3 are both 189 amino acids long, but isoform 2 (NP_789765) is shorter (170 amino acids) and has a distinct C-terminus. The mouse protein also has three isoforms, 1 and 2 are 189 amino acids long and isoform 2 (NP_001123916) is 188 amino acids. Two transcripts have been identified in the rat, both produce identical proteins of 189 amino acids.
Previous and Unofficial Names Click here for help
HRAS1 | transforming protein p21 | Harvey rat sarcoma viral oncogene homolog | Harvey rat sarcoma virus oncogene | HRas proto-oncogene, GTPase | HRas proto-oncogene
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
lonafarnib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.7 pIC50 1
pIC50 8.7 (IC50 1.9x10-9 M) [1]
Description: Measuring inhibition of farnesylation of HRAS by human farnesyltransferase
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
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GO:0050852 T cell receptor signaling pathway IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
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GO:0050852 T cell receptor signaling pathway IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0006897 endocytosis IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0042088 T-helper 1 type immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0042088 T-helper 1 type immune response IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0032729 positive regulation of interferon-gamma production IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Bladder cancer
Disease Ontology: DOID:11054
OMIM: 109800
Disease:  Costello syndrome; CSTLO
Disease Ontology: DOID:0050469
OMIM: 218040
Orphanet: ORPHA3071
Disease:  Nevus, epidermal
Disease Ontology: DOID:0050532
OMIM: 162900
Disease:  Phakomatosis pigmentokeratotica
Orphanet: ORPHA2874
Disease:  Schimmelpenning-Feuerstein-Mims syndrome; SFM
Synonyms: Linear nevus sebaceus syndrome [Orphanet: ORPHA2612]
OMIM: 163200
Orphanet: ORPHA2612
Disease:  Thyroid carcinoma, follicular; FTC
Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146]
Follicular thyroid carcinoma [Disease Ontology: DOID:3962]
Disease Ontology: DOID:3962
OMIM: 188470
Orphanet: ORPHA146

References

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1. Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N et al.. (1998) Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res., 58 (21): 4947-56. [PMID:9810004]

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