mercaptopurine [Ligand Id: 7226] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1425 (Mercaptopurine anhydrous) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 4.79 | pIC50 | 16242 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 | F | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| ChEMBL | Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7 | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| Purine nucleoside phosphorylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169594] [UniProtKB: P9WP01] | ||||||||
| ChEMBL | Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis | B | 4.1 | pKd | 79432.82 | nM | Kd | Bioorg Med Chem (2010) 18: 4769-4774 [PMID:20570524] |
| Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713] | ||||||||
| ChEMBL | Inhibition of mushroom tyrosinase | B | 4.8 | pKi | 16000 | nM | Ki | Eur J Med Chem (2020) 195: 112275-112275 [PMID:32283298] |
| ubiquitin specific peptidase 2/Ubiquitin carboxyl-terminal hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293227] [GtoPdb: 2430] [UniProtKB: O75604] | ||||||||
| ChEMBL | Inhibition of human USP2 (258 to 605 residues) catalytic domain by fluorescence based assay | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2020) 191: 112107-112107 [PMID:32092586] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
