levamisole [Ligand Id: 7210] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1454 (Levamisol, Levamisole, TCMDC-125847, Tetramisole, (s)-) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alkaline phosphatase, tissue-nonspecific isozyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5979] [UniProtKB: P05186] | ||||||||
| ChEMBL | Inhibition of TNSALP | B | 4.8 | pKi | 16000 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 222-225 [PMID:19038545] |
| ChEMBL | Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured after 20 mins by luminescence-based assay | B | 4.69 | pIC50 | 20210 | nM | IC50 | Eur J Med Chem (2018) 156: 461-478 [PMID:30015078] |
| ChEMBL | Inhibition of human TNAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by substrate addition and measured after 15 to 20 mins by spectrophotometric method | B | 4.69 | pIC50 | 20200 | nM | IC50 | Eur J Med Chem (2018) 159: 282-291 [PMID:30296687] |
| ChEMBL | Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by luminescence assay | B | 4.72 | pIC50 | 19200 | nM | IC50 | Eur J Med Chem (2018) 144: 116-127 [PMID:29268128] |
| ChEMBL | Inhibition of TNAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
| Alkaline phosphatase, tissue-nonspecific isozyme in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2406894] [UniProtKB: P09487] | ||||||||
| ChEMBL | Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method | B | 5.74 | pKi | 1810 | nM | Ki | Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133] |
| ChEMBL | Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method | B | 4.72 | pIC50 | 19210 | nM | IC50 | Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133] |
| ChEMBL | Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectrophotometric method | B | 4.72 | pIC50 | 19210 | nM | IC50 | Eur J Med Chem (2017) 126: 408-420 [PMID:27907877] |
| Intestinal alkaline phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5573] [UniProtKB: P09923] | ||||||||
| ChEMBL | Inhibition of human IAP using CDP-star as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins by spectrophotometric method | B | 4.69 | pIC50 | 20210 | nM | IC50 | Eur J Med Chem (2017) 131: 29-47 [PMID:28288318] |
| ChEMBL | Inhibition of IAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
| Phospholipase A-2-activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263] | ||||||||
| ChEMBL | Inhibition of PLAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
