pyridoxal 5-phosphate [Ligand Id: 5249] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL82202 (Pyridoxal phosphate, Pyridoxal Phosphate)
  • Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL Competitive inhibition of LMW-PTP isoform A (unknown origin) B 4.89 pKi 13000 nM Ki Bioorg Med Chem Lett (2020) 30: 127342-127342 [PMID:32631543]
P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575]
ChEMBL Antagonist activity at P2X1 receptor (unknown origin) B 5 pIC50 10000 nM IC50 Bioorg. Med. Chem. (2013) 21: 2643-2650 [PMID:23510563]
P2X1/P2X purinoceptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) F 5.52 pEC50 3000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2X2/P2X purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2531] [GtoPdb: 479] [UniProtKB: Q9UBL9]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 2 (P2X2) at 30 uM F 4.4 pEC50 39500 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]