pyridoxal 5-phosphate [Ligand Id: 5249] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL82202 (Pyridoxal phosphate, Pyridoxal Phosphate)
  • Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL Competitive inhibition of LMW-PTP isoform A (unknown origin) B 4.89 pKi 13000 nM Ki Bioorg Med Chem Lett (2020) 30: 127342-127342 [PMID:32631543]
P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575]
ChEMBL Antagonist activity at P2X1 receptor (unknown origin) B 5 pIC50 10000 nM IC50 Bioorg Med Chem (2013) 21: 2643-2650 [PMID:23510563]
P2X1/P2X purinoceptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) F 5.52 pEC50 3000 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2X2/P2X purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2531] [GtoPdb: 479] [UniProtKB: Q9UBL9]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 2 (P2X2) at 30 uM F 4.4 pEC50 39500 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]