pyridoxal 5-phosphate [Ligand Id: 5249] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL82202 (NSC-82388, Pyridoxal 5-phosphate, Pyridoxal 5'-phosphate, Pyridoxal phosphate, Pyridoxal Phosphate, Pyridoxal phosphate anhydrous)
  • Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL Competitive inhibition of LMW-PTP isoform A (unknown origin) B 4.89 pKi 13000 nM Ki Bioorg Med Chem Lett (2020) 30: 127342-127342 [PMID:32631543]
P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575]
ChEMBL Antagonist activity at P2X1 receptor (unknown origin) B 5 pIC50 10000 nM IC50 Bioorg Med Chem (2013) 21: 2643-2650 [PMID:23510563]
P2X1/P2X purinoceptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2530] [GtoPdb: 478] [UniProtKB: P47824]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) F 5.52 pEC50 3000 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2X2/P2X purinoceptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2531] [GtoPdb: 479] [UniProtKB: Q9UBL9]
ChEMBL The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 2 (P2X2) at 30 uM F 4.4 pEC50 39500 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]