NNC 11-1314 [Ligand Id: 291] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL99521
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 7.4 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
ChEMBL Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor F 7.8 pEC50 15.7 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 2897-2902 [PMID:9873644]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 7.2 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
ChEMBL Stimulation of cAMP in CHO cells expressing human m2 receptor F 7.21 pEC50 62 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 2897-2902 [PMID:9873644]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 7.7 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 7.3 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 7.8 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]