NNC 11-1314 [Ligand Id: 291] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL99521
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 7.4 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
ChEMBL Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor F 7.8 pEC50 15.7 nM EC50 Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 7.2 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
ChEMBL Stimulation of cAMP in CHO cells expressing human m2 receptor F 7.21 pEC50 62 nM EC50 Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 7.7 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 7.3 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 7.8 pKi - - - J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]