compound 35 [PMID: 23916259] [Ligand Id: 8842] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2420572 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Inhibition of human recombinant histidine-tagged full-length JNK1 expressed in insect cells using GST-tagged MAP2K7 as substrate after 1 hr by luminescence plate reader analysis | B | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-5222 [PMID:23916259] |
| GtoPdb | - | - | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-22 [PMID:23916259] |
| Microtubule associated serine/threonine kinase 3/Microtubule-associated serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417352] [GtoPdb: 1512] [UniProtKB: O60307] | ||||||||
| ChEMBL | Inhibition of MAST3 in human HuH7 cell lysates | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-5222 [PMID:23916259] |
| GtoPdb | - | - | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-22 [PMID:23916259] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
