buserelin   Click here for help

GtoPdb Ligand ID: 3860

Synonyms: buserelin acetate | HOE 766 | HOE 766A | ICI 123215 | Metrelef® | Suprefact®
Approved drug
buserelin is an approved drug
Compound class: Peptide
Comment: Buserelin is a GnRH (luteinizing hormone-releasing hormone, LHRH) agonist. Buserelin does not appear to have marketing approval for human use in the US or EU, although individual countries may have approved use of this drug.
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES CCNC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(Cc1ccc(cc1)O)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)CO)COC(C)(C)C)CC(C)C)CCCN=C(N)N
Isomeric SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)CO)COC(C)(C)C)CC(C)C)CCCN=C(N)N
InChI InChI=1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1
InChI Key CUWODFFVMXJOKD-UVLQAERKSA-N
Classification Click here for help
Compound class Peptide
Approved drug? Yes
IUPAC Name Click here for help
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
International Nonproprietary Names Click here for help
INN number INN
4045 buserelin
Synonyms Click here for help
buserelin acetate | HOE 766 | HOE 766A | ICI 123215 | Metrelef® | Suprefact®
Database Links Click here for help
Specialist databases
GPCRdb Ligand buserelin
Other databases
CAS Registry No. 57982-77-1 (source: Scifinder)
ChEMBL Ligand CHEMBL2110824
DrugBank Ligand DB06719
DrugCentral Ligand 436
GtoPdb PubChem SID 178100699
PubChem CID 50225
Search Google for chemical match using the InChIKey CUWODFFVMXJOKD-UVLQAERKSA-N
Search Google for chemicals with the same backbone CUWODFFVMXJOKD
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UniChem Compound Search for chemical match using the InChIKey CUWODFFVMXJOKD-UVLQAERKSA-N
UniChem Connectivity Search for chemical match using the InChIKey CUWODFFVMXJOKD-UVLQAERKSA-N
Wikipedia Buserelin