4-hydroxytamoxifen [Ligand Id: 2817] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL10041
  • Estrogen receptor-α in Human [GtoPdb: 620] [UniProtKB: P03372]
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  • Estrogen receptor-β in Human [GtoPdb: 621] [UniProtKB: Q92731]
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  • Estrogen-related receptor-γ in Human [GtoPdb: 624] [UniProtKB: P62508]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Estrogen receptor-α in Human [GtoPdb: 620] [UniProtKB: P03372]
GtoPdb - - 9.85 pKi - - - Endocrinology (1997) 138: 863-70 [PMID:9048584]
GtoPdb - - 9.85 pKi - - - Endocrinology (1997) 138: 863-70 [PMID:9048584]
GtoPdb - - 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2006) 16: 821-4 [PMID:16307879]
Estrogen receptor-β in Human [GtoPdb: 621] [UniProtKB: Q92731]
GtoPdb - - 10.6 pKi - - - Endocrinology (1997) 138: 863-70 [PMID:9048584]
Estrogen-related receptor-γ in Human [GtoPdb: 624] [UniProtKB: P62508]
GtoPdb - - 7.46 pKd 35 nM Kd Proc Natl Acad Sci USA (2001) 98: 8880-4 [PMID:11447273]
GtoPdb - - 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2006) 16: 821-4 [PMID:16307879]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]