ChEMBL ligand: CHEMBL826 (AT-2266, CI-919, Comprecin, Enoxacin, Flumark, NSC-629661, NSC-758416, PD 107779, PD-107779, Penetrex)
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
TAR RNA binding protein 2 in Human [ChEMBL: CHEMBL2098] [UniProtKB: Q15633] There should be some charts here, you may need to enable JavaScript!
V-type ATPase V1 motor B2 subunit/V-type proton ATPase subunit B, brain isoform in Human [ChEMBL: CHEMBL5641] [GtoPdb: 812] [UniProtKB: P21281] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6]
ChEMBL	Inhibition of Escherichia coli DNA gyrase GyrA/GyrB	B	4.85	pIC50	14000	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2909-2914 [PMID:18426901]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	4.11	pIC50	76800	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Antimalarial activity against blood stage form of Plasmodium falciparum assessed as incorporation of [3H]hypoxanthine after 72 hrs by liquid scintillation counting	F	4.7	pIC50	20000	nM	IC50	Eur J Med Chem (2014) 77: 280-287 [PMID:24650715]
TAR RNA binding protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2098] [UniProtKB: Q15633]
ChEMBL	Binding affinity to human recombinant TRBP by SPR assay	B	4.9	pKd	12560	nM	Kd	J Med Chem (2022) 65: 11010-11033 [PMID:35695407]
ChEMBL	Enhancement of His6-tagged TRBP (unknown origin) expressed in Escherichia coli BL21(DE3) binding to 32P-labeled Let7 precursor RNA assessed as TRBP Kd at 30 uM incubated for 60 mins by liquid scintillation counting method (Rvb = 221 nM)	B	7.03	pKd	94	nM	Kd	J Med Chem (2020) 63: 12275-12289 [PMID:32672457]
V-type ATPase V1 motor B2 subunit/V-type proton ATPase subunit B, brain isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5641] [GtoPdb: 812] [UniProtKB: P21281]
GtoPdb	Measuring inhibition of the interaction between the profilin-like domain of the B2 subunit and F-actin.	-	5	pIC50	10000	nM	IC50	J Med Chem (2009) 52: 5144-51 [PMID:19630402]
ChEMBL	Inhibition of maltose binding protein-fused human V-ATPase subunit B2 binding to F-actin	B	5	pIC50	10000	nM	IC50	J Med Chem (2009) 52: 5144-5151 [PMID:19630402]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]