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Compound class: Synthetic organic
Comment: Compound 5a causes microtubule fragmentation via modulation of the hydrolase activity of katanin . The precise binding site has not been determined, but could reside within catalytic site of KATNA1 (p60 subunit) due to the purine scaffold of 5a. A docking model suggests that 5a may bind in a position which stabilizes the p60 structure and enhances the microtubule severing activity of katanin.
Katanin-modulating compounds could provide an alternative to vinca alkaloid and taxane microtubule targeting agents (MTAs), which suffer from issues of drug-induced resistance developing in clinical use.
|Compound class||Synthetic organic|
|GtoPdb PubChem SID||318164819|
|Search Google for chemical match using the InChIKey||FFKCRLSRMMVTAN-UHFFFAOYSA-N|
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