(-)-sulpiride   Click here for help

GtoPdb Ligand ID: 958

Synonyms: S-(-)-sulpiride
Approved drug
(-)-sulpiride is an approved drug
Compound class: Synthetic organic
Comment: The (-)-enantiomer of sulpiride is approved with the INN levosulpiride and is also a component of the approved drug sulpiride.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

(-)-sulpiride is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 110.11
Molecular weight 341.14
XLogP 0.62
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N
Isomeric SMILES CCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N
InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
InChI Key BGRJTUBHPOOWDU-NSHDSACASA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name Click here for help
N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
International Nonproprietary Names Click here for help
INN number INN
6593 levosulpiride
2359 sulpiride
Synonyms Click here for help
S-(-)-sulpiride
Database Links Click here for help
Specialist databases
GPCRdb Ligand (-)-sulpiride
Other databases
BindingDB Ligand 81774
CAS Registry No. 23672-07-3 (source: SciFinder)
ChEBI CHEBI:64119
ChEMBL Ligand CHEMBL267044
DrugBank Ligand DB00391
DrugCentral Ligand 1577
GtoPdb PubChem SID 135651093
PubChem CID 688272
Search Google for chemical match using the InChIKey BGRJTUBHPOOWDU-NSHDSACASA-N
Search Google for chemicals with the same backbone BGRJTUBHPOOWDU
Search PubMed clinical trials sulpiride
Search PubMed titles sulpiride
Search PubMed titles/abstracts sulpiride
UniChem Compound Search for chemical match using the InChIKey BGRJTUBHPOOWDU-NSHDSACASA-N
UniChem Connectivity Search for chemical match using the InChIKey BGRJTUBHPOOWDU-NSHDSACASA-N
Wikipedia Sulpiride

Product suppliers

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Tocris
(S)-(-)-Sulpiride (links to external site)
Cat. No. 0895