ChEMBL ligand: CHEMBL907 (E-3174)
Angiotensin II type 1a (AT-1a) receptor in Bovine [ChEMBL: CHEMBL3374] [UniProtKB: P25104] Angiotensin II type 1a (AT-1a) receptor in Rabbit [ChEMBL: CHEMBL3948] [UniProtKB: P34976] There should be some charts here, you may need to enable JavaScript!
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351] There should be some charts here, you may need to enable JavaScript!
AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] There should be some charts here, you may need to enable JavaScript!
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] AT1 receptor/Type-1B angiotensin II receptor in Rat [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Angiotensin II type 1a (AT-1a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3374] [UniProtKB: P25104]
ChEMBL	In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex	B	7.66	pIC50	22	nM	IC50	J Med Chem (1996) 39: 323-338 [PMID:8568823]
ChEMBL	Inhibition of [125l]-All binding to bovine adrenal cortex	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem Lett (1994) 4: 177-182
Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976]
ChEMBL	Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response	F	10.09	pKd	0.08	nM	Kd	Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232]
ChEMBL	In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)	F	7.43	pIC50	37	nM	IC50	J Med Chem (1993) 36: 2558-2568 [PMID:8355255]
ChEMBL	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	B	8.22	pIC50	6	nM	IC50	J Med Chem (1994) 37: 4068-4072 [PMID:7990105]
ChEMBL	Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1	B	8.22	pIC50	6	nM	IC50	J Med Chem (1993) 36: 591-609 [PMID:8496939]
ChEMBL	In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)	F	8.22	pIC50	6	nM	IC50	J Med Chem (1993) 36: 2558-2568 [PMID:8355255]
ChEMBL	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	F	8.55	pIC50	2.8	nM	IC50	J Med Chem (1993) 36: 3595-3605 [PMID:8246227]
ChEMBL	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	B	8.55	pIC50	2.8	nM	IC50	J Med Chem (1994) 37: 2808-2824 [PMID:8064808]
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351]
ChEMBL	In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (1994) 37: 2808-2824 [PMID:8064808]
ChEMBL	In vitro binding affinity for angiotensin II AT2 receptor in rat midbrain	B	4.3	pIC50	50000	nM	IC50	J Med Chem (1994) 37: 4068-4072 [PMID:7990105]
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL	Inhibition of ATR1 (unknown origin)	B	8.7	pIC50	2	nM	IC50	J Med Chem (2019) 62: 8915-8930 [PMID:31083946]
GtoPdb	-	-	9.49	pIC50	0.32	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]; Pharmacol Rev (1993) 45: 205-51 [PMID:8372104]
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb	-	-	9.49	pIC50	0.32	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]; Pharmacol Rev (1993) 45: 205-51 [PMID:8372104]
AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089]
ChEMBL	In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1	F	7.43	pIC50	37	nM	IC50	J Med Chem (1993) 36: 591-609 [PMID:8496939]
ChEMBL	Concentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue	B	7.96	pIC50	11	nM	IC50	J Med Chem (1992) 35: 2658-2667 [PMID:1635064]
ChEMBL	Binding affinity against AT1 receptor in the presence of 0.01% BSA	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (1994) 37: 1632-1645 [PMID:8201597]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]