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ChEMBL ligand: CHEMBL88606 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 | B | 4.88 | pIC50 | 13300 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
ChEMBL | Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase | B | 5.31 | pIC50 | 4920 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2000) 43: 2655-63 [PMID:10893303] |
ChEMBL | Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2 | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]