Synonyms: trans‐4‐butylcyclohexane carboxylic acid
Compound class:
Synthetic organic
Comment: X-ray crystallography shows that 4‐BCCA inhibits AMPA receptor activity by binding (with low‐affinity) to a region in the receptor's transmembrane domain (PDB ID 6XSR) [1]. The interaction was confirmed by mutagenesis of the amino acids predicted to be involved in the ligand-receptor interaction by the X-ray structure and electropysiological measurements in vitro. This discovery helps to explain the molecular mechanism underlying 4‐BCCA's anti-epileptic activity.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-butylcyclohexane-1-carboxylic acid |
Synonyms ![]() |
trans‐4‐butylcyclohexane carboxylic acid |
Database Links ![]() |
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GtoPdb PubChem SID | 434321744 |
PubChem CID | 2060518 |
Search Google for chemical match using the InChIKey | BALGERHMIXFENA-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | BALGERHMIXFENA |
UniChem Compound Search for chemical match using the InChIKey | BALGERHMIXFENA-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BALGERHMIXFENA-UHFFFAOYSA-N |