SB-747651A [Ligand Id: 8130] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL188434 (SB-747651, SB-747651A) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibitory concentration against selected kinase CDK2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3407-3411 [PMID:15955699] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
| ChEMBL | Inhibitory concentration against selected kinase DYRK1-alpha | B | 5.31 | pIC50 | 4900 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3407-3411 [PMID:15955699] |
| CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] | ||||||||
| ChEMBL | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate | F | 5.68 | pIC50 | 2070 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
| ChEMBL | Inhibitory concentration against selected kinase ROCK1 | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3407-3411 [PMID:15955699] |
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5509] [GtoPdb: 1503] [UniProtKB: Q63644] | ||||||||
| ChEMBL | Inhibition of rat ROCK1 | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (2008) 51: 5663-5679 [PMID:18800763] |
| ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
| ChEMBL | Inhibitory concentration against selected kinase p70S6K | B | 6.57 | pIC50 | 270 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3407-3411 [PMID:15955699] |
| ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
| ChEMBL | Inhibition of MSK1 | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2008) 51: 5663-5679 [PMID:18800763] |
| GtoPdb | - | - | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3407-11 [PMID:15955699] |
| ChEMBL | Inhibitory concentration against MSK-1 | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3407-3411 [PMID:15955699] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of human AKT1 | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2008) 51: 5663-5679 [PMID:18800763] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Inhibition of human AKT2 | B | 6.13 | pIC50 | 741 | nM | IC50 | J Med Chem (2008) 51: 5663-5679 [PMID:18800763] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Inhibition of human AKT3 | B | 6.19 | pIC50 | 646 | nM | IC50 | J Med Chem (2008) 51: 5663-5679 [PMID:18800763] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
