donanemab   Click here for help

GtoPdb Ligand ID: 8357

Compound class: Antibody
Comment: Donanemab (LY3002813) is a monoclonal antibody developed from the murine monoclonal mE8-IgG2a [1]. It binds to N-terminally, pyroglutamate-modified amyloid β proteins (abbreviated as Aβp3-x or N3pG) which are found extensively in the amyloid plaques of the brains of Alzheimer's disease (AD) patients. The removal of Aβp3-x is being investigated as a novel mechanism to treat AD.
Classification Click here for help
Compound class Antibody
Database Links Click here for help
GtoPdb PubChem SID 252166569