propylthiouracil [Ligand Id: 6650] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1518 (NSC-6498, NSC-70461, Propacil, Propylthiouracil, Prothyran, Thyreostat, Thyreostat ii) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
| ChEMBL | Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysis | B | 5.24 | pIC50 | 5700 | nM | IC50 | J Med Chem (2015) 58: 8513-8528 [PMID:26509551] |
| ChEMBL | Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin after 300 secs by spectrophotometric analysis | B | 5.55 | pIC50 | 2810 | nM | IC50 | J Med Chem (2015) 58: 8513-8528 [PMID:26509551] |
| TAS2R38/Taste receptor type 2 member 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523248] [GtoPdb: 682] [UniProtKB: P59533] | ||||||||
| GtoPdb | - | - | 5.68 | pEC50 | 2100 | nM | EC50 | Curr Biol (2005) 15: 322-7 [PMID:15723792] |
| ChEMBL | Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay | F | 5.7 | pEC50 | 2000 | nM | EC50 | EP-2267129-B1. Bitter taste receptors (2015) |
| thyroid peroxidase/Thyroid peroxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1839] [GtoPdb: 2526] [UniProtKB: P07202] | ||||||||
| ChEMBL | Inhibition of TPO (unknown origin) using Amplex Red as substrate assessed as formation of resorufin measured every 20 secs by spectrophotometric analysis | B | 5.47 | pIC50 | 3380 | nM | IC50 | J Med Chem (2015) 58: 8513-8528 [PMID:26509551] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
