(S)-liquiritigenin [Ligand Id: 8899] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL252642 ((2S)-Liquiritigenin, 4',7-Dihydroxyflavanone, 7,4'-Dihydroxyflavanone, Liquiritigenin, Liquirtigenin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's method | B | 5.04 | pIC50 | 9100 | nM | IC50 | Bioorg Med Chem Lett (2021) 52: 128306-128306 [PMID:34371131] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate incubated for 15 to 20 mins by Ellman's method | B | 4.85 | pIC50 | 14040 | nM | IC50 | Bioorg Med Chem Lett (2021) 52: 128306-128306 [PMID:34371131] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of human aromatase in placental microsomes | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem (2008) 16: 1474-1480 [PMID:18042388] |
| ChEMBL | Inhibition of human aromatase by fluorometric assay | B | 6.47 | pIC50 | 340 | nM | IC50 | Bioorg Med Chem (2008) 16: 8466-8470 [PMID:18778944] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] | ||||||||
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay | B | 5.08 | pIC50 | 8330 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
| ChEMBL | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay | B | 5.68 | pIC50 | 2070 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
| proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| ChEMBL | Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as substrate preincubated for 10 mins and measured by fluorescence based method | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2019) 167: 291-311 [PMID:30776692] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 mins | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2011) 19: 3378-3383 [PMID:21571537] |
| ChEMBL | Inhibition of human recombinant PTP1B | B | 4.22 | pIC50 | >60000 | nM | IC50 | J Nat Prod (2006) 69: 1572-1576 [PMID:17125223] |
| ChEMBL | Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5155-5157 [PMID:19632832] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Inhibition of YES (unknown origin) | B | 4.95 | pIC50 | 11300 | nM | IC50 | Eur J Med Chem (2019) 166: 186-196 [PMID:30769179] |
| Xanthine dehydrogenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3649] [UniProtKB: P80457] | ||||||||
| ChEMBL | Inhibition of cow milk xanthine oxidase | B | 4.95 | pIC50 | 11300 | nM | IC50 | J Nat Prod (1988) 51: 345-348 [PMID:3379415] |
| TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] | ||||||||
| GtoPdb | - | - | 5.2 | pIC50 | - | - | - | Mol Pharmacol (2013) 84: 736-50 [PMID:24006495] |
| Estrogen receptor-β in Human [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| GtoPdb | Measuring activation of the ERE tk-Luc reporter by ER&bets; in transfected U2OS cells. | - | 7.44 | pEC50 | 36.5 | nM | EC50 | Mol Cell Endocrinol (2008) 283: 49-57 [PMID:18177995] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
