CGP37849 [Ligand Id: 4154] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL29811 (CGP-37849) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] | ||||||||
| ChEMBL | Tested for the inhibitory activity by the inhibition of excitatory L-[3H]Glutamate binding to NMDA recognition sites | B | 7.59 | pIC50 | 25.7 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 27-32 |
| ChEMBL | Tested for the inhibitory activity by the inhibition of excitatory [3H]CGS-19,755 binding to NMDA recognition sites | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 27-32 |
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Compound was evaluated for its ability to displace [3H]CPP or [3H]-CGS- 19755 ligand from N-methyl-D-aspartate (NMDA) receptor | B | 6 | pKi | <1000 | nM | Ki | J Med Chem (1992) 35: 1509-1514 [PMID:1533680] |
| ChEMBL | Compound was evaluated for its ability to displace [3H]-CPP ligand from N-methyl-D-aspartate (NMDA) receptor | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (1992) 35: 1509-1514 [PMID:1533680] |
| ChEMBL | Ability to displace [3H]CPP from NMDA receptor in rat brain membrane | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1992) 35: 1345-1370 [PMID:1533422] |
| GluN2A/Glutamate [NMDA] receptor subunit epsilon 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL310] [GtoPdb: 456] [UniProtKB: Q00959] | ||||||||
| ChEMBL | Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2005) 48: 5489-5494 [PMID:16107147] |
| ChEMBL | Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2005) 48: 5489-5494 [PMID:16107147] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
