CGP37849 [Ligand Id: 4154] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL29811 (CGP-37849) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] | ||||||||
| ChEMBL | Tested for the inhibitory activity by the inhibition of excitatory L-[3H]Glutamate binding to NMDA recognition sites | B | 7.59 | pIC50 | 25.7 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 27-32 |
| ChEMBL | Tested for the inhibitory activity by the inhibition of excitatory [3H]CGS-19,755 binding to NMDA recognition sites | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 27-32 |
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Compound was evaluated for its ability to displace [3H]CPP or [3H]-CGS- 19755 ligand from N-methyl-D-aspartate (NMDA) receptor | B | 6 | pKi | <1000 | nM | Ki | J Med Chem (1992) 35: 1509-1514 [PMID:1533680] |
| ChEMBL | Compound was evaluated for its ability to displace [3H]-CPP ligand from N-methyl-D-aspartate (NMDA) receptor | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (1992) 35: 1509-1514 [PMID:1533680] |
| ChEMBL | Ability to displace [3H]CPP from NMDA receptor in rat brain membrane | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1992) 35: 1345-1370 [PMID:1533422] |
| GluN2A/Glutamate [NMDA] receptor subunit epsilon 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL310] [GtoPdb: 456] [UniProtKB: Q00959] | ||||||||
| ChEMBL | Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2005) 48: 5489-5494 [PMID:16107147] |
| ChEMBL | Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2005) 48: 5489-5494 [PMID:16107147] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
