compound 1 [PMID: 24793884] [Ligand Id: 8218] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3261228 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7] | ||||||||
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.188 uM of ATP as substrate by AlphaScreen assay | B | 6.26 | pIC50 | 547 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.375 uM of ATP as substrate by AlphaScreen assay | B | 6.26 | pIC50 | 546 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.094 uM of ATP as substrate by AlphaScreen assay | B | 6.28 | pIC50 | 528 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 3 uM of ATP as substrate by AlphaScreen assay | B | 6.38 | pIC50 | 419 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.047 uM of ATP as substrate by AlphaScreen assay | B | 6.39 | pIC50 | 405 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| GtoPdb | - | - | 6.49 | pIC50 | 323 | nM | IC50 | Eur J Med Chem (2014) 80: 364-82 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay | B | 6.49 | pIC50 | 323 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 1.5 uM of ATP as substrate by AlphaScreen assay | B | 6.5 | pIC50 | 318 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.75 uM of ATP as substrate by AlphaScreen assay | B | 6.5 | pIC50 | 316 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
| ChEMBL | Inhibition of Cdc7/Dbf4 (unknown origin) using 0.023 uM of ATP as substrate by AlphaScreen assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2014) 80: 364-382 [PMID:24793884] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
