compound 1 [PMID: 24793884] [Ligand Id: 8218] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3261228
  • cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311Q9UBU7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311Q9UBU7]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 0.188 uM of ATP as substrate by AlphaScreen assay B 6.26 pIC50 547 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 0.375 uM of ATP as substrate by AlphaScreen assay B 6.26 pIC50 546 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 0.094 uM of ATP as substrate by AlphaScreen assay B 6.28 pIC50 528 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 3 uM of ATP as substrate by AlphaScreen assay B 6.38 pIC50 419 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 0.047 uM of ATP as substrate by AlphaScreen assay B 6.39 pIC50 405 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
GtoPdb - - 6.49 pIC50 323 nM IC50 Eur J Med Chem (2014) 80: 364-82 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay B 6.49 pIC50 323 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 1.5 uM of ATP as substrate by AlphaScreen assay B 6.5 pIC50 318 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 0.75 uM of ATP as substrate by AlphaScreen assay B 6.5 pIC50 316 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]
ChEMBL Inhibition of Cdc7/Dbf4 (unknown origin) using 0.023 uM of ATP as substrate by AlphaScreen assay B 6.52 pIC50 300 nM IC50 Eur. J. Med. Chem. (2014) 80: 364-382 [PMID:24793884]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]