ChEMBL ligand: CHEMBL1023 (Bexarotene, LG100069, LG-100069, LGD1069, LGD-1069, NSC-747528, Targretin, Targretine)
CYP26A1/Cytochrome P450 26A1 in Human [ChEMBL: CHEMBL5141] [GtoPdb: 1366] [UniProtKB: O43174] There should be some charts here, you may need to enable JavaScript!
CYP26B1/Cytochrome P450 26B1 in Human [ChEMBL: CHEMBL3713687] [GtoPdb: 1367] [UniProtKB: Q9NR63] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-β/LXR-beta in Human [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha in Human [ChEMBL: CHEMBL3885613] [GtoPdb: 610, 630] [UniProtKB: P19793, P43354] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] Retinoid X receptor-α/Retinoid X receptor alpha in Mouse [ChEMBL: CHEMBL3084] [GtoPdb: 610] [UniProtKB: P28700] Retinoid X receptor-α/Retinoid X receptor alpha in Rat [ChEMBL: CHEMBL4431] [GtoPdb: 610] [UniProtKB: Q05343] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-β/Retinoid X receptor beta in Human [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] Retinoid X receptor-β/Retinoid X receptor beta in Mouse [ChEMBL: CHEMBL4047] [GtoPdb: 611] [UniProtKB: P28704] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-γ/Retinoid X receptor gamma in Human [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] Retinoid X receptor-γ/Retinoid X receptor gamma in Mouse [ChEMBL: CHEMBL4402] [GtoPdb: 612] [UniProtKB: P28705] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP26A1/Cytochrome P450 26A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5141] [GtoPdb: 1366] [UniProtKB: O43174]
ChEMBL	Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase	B	4.87	pIC50	13500	nM	IC50	J Med Chem (2016) 59: 2579-2595 [PMID:26918322]
CYP26B1/Cytochrome P450 26B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3713687] [GtoPdb: 1367] [UniProtKB: Q9NR63]
ChEMBL	Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase	B	5.23	pIC50	5900	nM	IC50	J Med Chem (2016) 59: 2579-2595 [PMID:26918322]
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL	Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	B	6.71	pEC50	196	nM	EC50	Bioorg Med Chem Lett (2017) 27: 1193-1198 [PMID:28169169]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL	Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay	B	6.36	pEC50	434	nM	EC50	Bioorg Med Chem Lett (2017) 27: 1193-1198 [PMID:28169169]
Retinoid X receptor-α/Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885613] [GtoPdb: 610, 630] [UniProtKB: P19793, P43354]
GtoPdb	-	-	7.4	pIC50	-	-	-	Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]; J Med Chem (1999) 42: 742-50 [PMID:10052980]; J Med Chem (1994) 37: 2930-41 [PMID:8071941]
ChEMBL	Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha/Nurr1 (unknown origin) expressed in HEK293T cells by BRET2 assay	B	8	pEC50	10	nM	EC50	J Med Chem (2016) 59: 1232-1238 [PMID:26820900]
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha	B	6	pKd	>1000	nM	Kd	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Inhibition of [3H]ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha	B	5.26	pKi	5453	nM	Ki	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Inhibition of [3H]ATRA binding to RAR alpha receptor	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Inhibition of [3H]ATRA binding to retinoic acid receptor RAR alpha	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Selective activity towards retinoic acid receptor-alpha	B	6.74	pKi	180	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
ChEMBL	Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Agonist activity at RARaplha (unknown origin)	B	5	pEC50	>10000	nM	EC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha	F	8.22	pEC50	6	nM	EC50	J Med Chem (1999) 42: 742-750 [PMID:10052980]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Inhibition of [3H]ATRA binding to baculovirus expressed retinoid receptor RAR beta	B	6	pKd	>1000	nM	Kd	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Inhibition of [3H]ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta	B	5.27	pKi	5353	nM	Ki	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Inhibition of [3H]ATRA binding to RAR beta receptor	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Inhibition of [3H]ATRA binding to retinoic acid receptor RAR beta	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA	B	6.1	pKi	>800	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2313-2318
ChEMBL	Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA	B	6.26	pKi	>550	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2313-2318
ChEMBL	Selective activity towards retinoic acid receptor-beta	B	7.3	pKi	50	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
ChEMBL	Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Agonist activity at RARbeta (unknown origin)	B	5	pEC50	>10000	nM	EC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta	F	6.55	pEC50	282	nM	EC50	J Med Chem (1999) 42: 742-750 [PMID:10052980]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus	B	6	pKd	>1000	nM	Kd	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma	B	5.49	pKi	3206	nM	Ki	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Inhibition of [3H]ATRA binding to RAR gamma receptor	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Selective activity towards retinoic acid receptor-gamma	B	6.89	pKi	130	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
ChEMBL	Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Agonist activity at RARgamma (unknown origin)	B	5	pEC50	>10000	nM	EC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma	F	6.19	pEC50	648	nM	EC50	J Med Chem (1999) 42: 742-750 [PMID:10052980]
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL	Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by isothermal titration calorimetry	B	5.72	pKd	1890	nM	Kd	J Med Chem (2014) 57: 5370-5380 [PMID:24801499]
ChEMBL	Binding affinity to human RXRalpha LBD after 15 mins by isothermal titration calorimetry assay	B	5.8	pKd	1590	nM	Kd	J Med Chem (2015) 58: 7763-7774 [PMID:26331194]
ChEMBL	Binding affinity to recombinant RXRalpha (unknown origin) by isothermal titration calorimetry	B	6.68	pKd	210	nM	Kd	J Med Chem (2019) 62: 2112-2126 [PMID:30702885]
ChEMBL	Dissociation constant for binding to Retinoic acid receptor RXR-alpha	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem Lett (2002) 12: 2607-2609 [PMID:12182871]
ChEMBL	Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.	B	7.44	pKd	36	nM	Kd	J Med Chem (1995) 38: 3146-3155 [PMID:7636877]
ChEMBL	Binding affinity to human RXRalpha ligand binding domain by fluorescence assay	B	7.59	pKd	26	nM	Kd	Bioorg Med Chem (2014) 22: 178-185 [PMID:24359708]
ChEMBL	Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching method	B	7.59	pKd	26	nM	Kd	J Med Chem (2014) 57: 5370-5380 [PMID:24801499]
ChEMBL	Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha	B	7.85	pKd	14	nM	Kd	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assay	B	6.42	pKi	379	nM	Ki	J Med Chem (2019) 62: 8809-8818 [PMID:31483660]
ChEMBL	Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr in presence of compound by fluorescence polarization assay	B	6.46	pKi	350	nM	Ki	ACS Med Chem Lett (2021) 12: 1024-1029 [PMID:34141088]
ChEMBL	Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr in presence of compound by [3H]9-Cis retinoic acid assay	B	6.7	pKi	201	nM	Ki	ACS Med Chem Lett (2021) 12: 1024-1029 [PMID:34141088]
ChEMBL	Displacement of 9-cis-[11,12-3H]-retinoic acid from human RXRalpha LBD incubated for overnight by scintillation counting method	B	6.82	pKi	150	nM	Ki	J Med Chem (2019) 62: 8809-8818 [PMID:31483660]
ChEMBL	Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-alpha in baculoviral system, by using 5 nM [3H]targretin in a competitive binding assay	B	7.44	pKi	36	nM	Ki	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alpha	B	7.44	pKi	36	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Displacement of [3H]9-cis-retinoic acid form human RXRalpha expressed in human Caco-2 cells after 16 hrs	B	7.68	pKi	21	nM	Ki	J Med Chem (2009) 52: 5950-5966 [PMID:19791803]
ChEMBL	Selective activity towards retinoid X receptor-alpha	B	7.8	pKi	16	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
ChEMBL	Inhibition of [3H]9-cis-RA binding to RXR alpha receptor	B	7.85	pKi	14	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr in presence of compound by fluorescence polarization assay	B	6.2	pIC50	632	nM	IC50	ACS Med Chem Lett (2021) 12: 1024-1029 [PMID:34141088]
GtoPdb	-	-	7.4	pIC50	-	-	-	Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]; J Med Chem (1999) 42: 742-50 [PMID:10052980]; J Med Chem (1994) 37: 2930-41 [PMID:8071941]
ChEMBL	Transactivation of human RXRalpha transfected in human 293 cells after 48 hrs by dual-luciferase reporter gene assay	B	6.83	pEC50	149	nM	EC50	Bioorg Med Chem Lett (2013) 23: 3891-3895 [PMID:23707260]
ChEMBL	Agonist activity at RXRalpha LBD (unknown origin) expressed in CV1 cells	B	6.93	pEC50	118	nM	EC50	J Med Chem (2015) 58: 7763-7774 [PMID:26331194]
ChEMBL	Agonist activity at human recombinant Gal4-tagged RXRalpha expressed in human Caco-2 cells assessed as receptor homodimerization after 24 hrs by mammalian two hybrid assay	F	7.28	pEC50	52	nM	EC50	J Med Chem (2009) 52: 5950-5966 [PMID:19791803]
ChEMBL	Effective concentration against Retinoic acid receptor RXR-alpha	B	7.38	pEC50	42	nM	EC50	J Med Chem (1995) 38: 3368-3383 [PMID:7650690]
ChEMBL	Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay	B	7.4	pEC50	40	nM	EC50	J Med Chem (2014) 57: 5370-5380 [PMID:24801499]
ChEMBL	Agonist activity at human RXRalpha expressed in African green monkey CV1 cells	B	7.48	pEC50	33	nM	EC50	Medchemcomm (2018) 9: 1289-1292 [PMID:30151082]
ChEMBL	Agonist activity RXRalpha (unknown origin)	B	7.48	pEC50	33	nM	EC50	J Med Chem (2019) 62: 2112-2126 [PMID:30702885]
ChEMBL	Agonist activity at RXRaplha (unknown origin)	B	7.48	pEC50	33	nM	EC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells	B	7.48	pEC50	33	nM	EC50	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha	F	7.48	pEC50	33	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene assay	B	7.5	pEC50	31.62	nM	EC50	J Med Chem (2016) 59: 1232-1238 [PMID:26820900]
ChEMBL	Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay	B	7.5	pEC50	31.62	nM	EC50	J Med Chem (2016) 59: 1232-1238 [PMID:26820900]
ChEMBL	Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alpha	F	7.55	pEC50	28	nM	EC50	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.	B	7.55	pEC50	28	nM	EC50	J Med Chem (1995) 38: 3146-3155 [PMID:7636877]
ChEMBL	Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR alpha	F	7.55	pEC50	28	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assay	B	7.66	pEC50	22	nM	EC50	J Med Chem (2019) 62: 8809-8818 [PMID:31483660]
ChEMBL	Agonist activity at human RXRalpha expressed in African green monkey COS1 cells harboring CRBP2-tk-luc reporter incubated for 18 hrs by steady-glo luciferase reporter gene assay	B	7.7	pEC50	20	nM	EC50	Bioorg Med Chem Lett (2019) 29: 1891-1894 [PMID:31160175]
ChEMBL	Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay	F	7.7	pEC50	20	nM	EC50	ACS Med Chem Lett (2010) 1: 521-525 [PMID:24900241]
ChEMBL	Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assay	B	7.7	pEC50	20	nM	EC50	ACS Med Chem Lett (2015) 6: 334-338 [PMID:25815156]
ChEMBL	Agonist activity at RXRalpha by luciferase reporter gene assay	F	7.7	pEC50	19.8	nM	EC50	Bioorg Med Chem Lett (2010) 20: 5139-5142 [PMID:20656484]
ChEMBL	Agonist activity at human RXRalpha LBD by cell based luciferase reporter gene assay	F	8.57	pEC50	2.7	nM	EC50	J Med Chem (2011) 54: 788-808 [PMID:21218783]
Retinoid X receptor-α/Retinoid X receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3084] [GtoPdb: 610] [UniProtKB: P28700]
ChEMBL	Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay	B	7.4	pEC50	40	nM	EC50	Eur J Med Chem (2009) 44: 2434-2446 [PMID:19216008]
Retinoid X receptor-α/Retinoid X receptor alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4431] [GtoPdb: 610] [UniProtKB: Q05343]
ChEMBL	Agonist activity at RXRalpha in rat RK3E cells assessed as transcriptional activation by luciferase reporter gene assay	B	7.4	pEC50	40	nM	EC50	Bioorg Med Chem (2014) 22: 178-185 [PMID:24359708]
Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702]
ChEMBL	Inhibition of [3H]9-cis-RA binding to RXR beta receptor	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-beta in baculoviral system, by using 5 nM [3H]targretin in a competitive binding assay	B	7.68	pKi	21	nM	Ki	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Selective activity towards retinoid X receptor-beta	B	8.23	pKi	5.9	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
GtoPdb	-	-	7.7	pIC50	-	-	-	Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]; J Med Chem (1999) 42: 742-50 [PMID:10052980]; J Med Chem (1994) 37: 2930-41 [PMID:8071941]
ChEMBL	Effective concentrations against Retinoic acid receptor RXR-beta	B	6.95	pEC50	112	nM	EC50	J Med Chem (1995) 38: 3368-3383 [PMID:7650690]
ChEMBL	Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-beta	F	7.6	pEC50	25	nM	EC50	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta	F	7.62	pEC50	24	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Agonist activity at RXRbeta (unknown origin)	B	7.62	pEC50	24	nM	EC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Agonist activity at human RXRbeta expressed in African green monkey CV1 cells	B	7.62	pEC50	24	nM	EC50	Medchemcomm (2018) 9: 1289-1292 [PMID:30151082]
ChEMBL	Agonist activity RXRbeta (unknown origin)	B	7.62	pEC50	24	nM	EC50	J Med Chem (2019) 62: 2112-2126 [PMID:30702885]
Retinoid X receptor-β/Retinoid X receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4047] [GtoPdb: 611] [UniProtKB: P28704]
ChEMBL	Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay.	B	7.68	pKd	21	nM	Kd	J Med Chem (1995) 38: 3146-3155 [PMID:7636877]
ChEMBL	Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta	B	7.68	pKd	21	nM	Kd	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR beta	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.	B	7.6	pEC50	25	nM	EC50	J Med Chem (1995) 38: 3146-3155 [PMID:7636877]
ChEMBL	Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR beta	F	7.6	pEC50	25	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells	B	7.62	pEC50	24	nM	EC50	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443]
ChEMBL	Binding affinity towards Retinoic acid receptor RXR-gamma	B	7.12	pKi	75	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2313-2318
ChEMBL	Inhibition of [3H]9-cis-RA binding to RXR gamma receptor	B	7.54	pKi	29	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-gamma in baculoviral system, by using 5 nM [3H]targretin in a competitive binding assay	B	7.54	pKi	29	nM	Ki	J Med Chem (1999) 42: 742-750 [PMID:10052980]
ChEMBL	Selective activity towards retinoid X receptor-gamma	B	8.08	pKi	8.3	nM	Ki	J Med Chem (1997) 40: 4222-4234 [PMID:9435893]
GtoPdb	-	-	7.54	pIC50	-	-	-	Curr Pharm Des (2000) 6: 25-58 [PMID:10637371]; J Med Chem (1999) 42: 742-50 [PMID:10052980]; J Med Chem (1994) 37: 2930-41 [PMID:8071941]
ChEMBL	Effective concentrations against Retinoic acid receptor RXR-gamma	B	6.91	pEC50	122	nM	EC50	J Med Chem (1995) 38: 3368-3383 [PMID:7650690]
ChEMBL	Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma	F	7.6	pEC50	25	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2747-2752
ChEMBL	Agonist activity at RXRgamma (unknown origin)	B	7.6	pEC50	25	nM	EC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Agonist activity at human RXRgamma expressed in African green monkey CV1 cells	B	7.6	pEC50	25	nM	EC50	Medchemcomm (2018) 9: 1289-1292 [PMID:30151082]
ChEMBL	Agonist activity RXRgamma (unknown origin)	B	7.6	pEC50	25	nM	EC50	J Med Chem (2019) 62: 2112-2126 [PMID:30702885]
ChEMBL	Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gamma	F	7.7	pEC50	20	nM	EC50	J Med Chem (1999) 42: 742-750 [PMID:10052980]
Retinoid X receptor-γ/Retinoid X receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4402] [GtoPdb: 612] [UniProtKB: P28705]
ChEMBL	Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay.	B	7.54	pKd	29	nM	Kd	J Med Chem (1995) 38: 3146-3155 [PMID:7636877]
ChEMBL	Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma	B	7.54	pKd	29	nM	Kd	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR gamma	B	7.54	pKi	29	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2393-2398
ChEMBL	Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells	B	7.6	pEC50	25	nM	EC50	J Med Chem (1994) 37: 2930-2941 [PMID:8071941]
ChEMBL	Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.	B	7.7	pEC50	20	nM	EC50	J Med Chem (1995) 38: 3146-3155 [PMID:7636877]
ChEMBL	Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gamma	B	7.7	pEC50	20	nM	EC50	Bioorg Med Chem Lett (1997) 7: 2393-2398
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
GtoPdb	Measured using a TR-FRET competitive displacement assay.	-	5.52	pIC50	~3000	nM	IC50	PPAR Res (2015) 2015: 254560 [PMID:26451138]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]