temocaprilat [Ligand Id: 11737] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL300841 (RNH-5139, RS-5139, Temocaprilat, Temocapril diacid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibitory activity against rabbit lung Angiotensin I converting enzyme with 5 mM hippuryl-histidyl-leucine as substrate | B | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (1987) 30: 1984-1991 [PMID:3669006] |
| Angiotensin-converting enzyme in Rabbit [GtoPdb: 1613] | ||||||||
| GtoPdb | Inhibition of ACE activity, using hippuryl-histidyl-leucine as substrate, and ACE from rabbit lung. | - | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (1987) 30: 1984-91 [PMID:3669006] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
