ChEMBL ligand: CHEMBL302196 (A-304121)
H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] There should be some charts here, you may need to enable JavaScript!
H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] H3 receptor/Histamine H3 receptor in Rat [ChEMBL: CHEMBL4124] [GtoPdb: 264] [UniProtKB: Q9QYN8] Histamine H3 receptor in Guinea pig [ChEMBL: CHEMBL5076] [UniProtKB: Q9JI35] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL	Binding affinity towards Histamine H1 receptor of human membranes.	B	4.16	pKi	69183.1	nM	Ki	Bioorg. Med. Chem. Lett. (2002) 12: 2035-2037 [PMID:12113836]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	Binding affinity towards Histamine H2 receptor from human membranes	B	4.15	pKi	70794.58	nM	Ki	Bioorg. Med. Chem. Lett. (2002) 12: 2035-2037 [PMID:12113836]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL	Binding affinity to human histamine H3 receptor	B	6.1	pKi	794.33	nM	Ki	J. Med. Chem. (2011) 54: 26-53 [PMID:21062081]
GtoPdb	-	-	6.1	pKi	-	-	-	J Pharmacol Exp Ther (2003) 305: 887-96 [PMID:12606603]; Biochem Pharmacol (2004) 68: 933-45 [PMID:15294456]
ChEMBL	Binding affinity for human histamine H3 receptor on human colon cells	B	6.12	pKi	760	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 673-676 [PMID:14741266]
ChEMBL	In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor	B	6.12	pKi	760	nM	Ki	J. Med. Chem. (2005) 48: 38-55 [PMID:15634000]
ChEMBL	In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor	B	6.12	pKi	758.58	nM	Ki	J. Med. Chem. (2005) 48: 38-55 [PMID:15634000]
H3 receptor/Histamine H3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4124] [GtoPdb: 264] [UniProtKB: Q9QYN8]
ChEMBL	In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor	B	8.6	pKi	2.51	nM	Ki	J. Med. Chem. (2005) 48: 38-55 [PMID:15634000]
ChEMBL	Binding affinity to rat cortical histamine H3 receptor	B	8.6	pKi	2.51	nM	Ki	J. Med. Chem. (2011) 54: 26-53 [PMID:21062081]
GtoPdb	-	-	8.6	pKi	-	-	-	J Pharmacol Exp Ther (2003) 305: 887-96 [PMID:12606603]; Biochem Pharmacol (2004) 68: 933-45 [PMID:15294456]
ChEMBL	In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor	B	8.6	pKi	2.5	nM	Ki	J. Med. Chem. (2005) 48: 38-55 [PMID:15634000]
ChEMBL	Binding affinity towards Histamine H3 receptor of rat cortical membranes.	B	8.9	pKi	1.26	nM	Ki	Bioorg. Med. Chem. Lett. (2002) 12: 2035-2037 [PMID:12113836]
Histamine H3 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5076] [UniProtKB: Q9JI35]
ChEMBL	Tested in vitro for histamine H3 receptor mediate inhibition of neurogenic contractions in guinea pig isolated ileum assay	F	6.98	pKd	104.71	nM	Kd	Bioorg. Med. Chem. Lett. (2002) 12: 2035-2037 [PMID:12113836]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]