zotepine [Ligand Id: 103] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL285802 (Nipolept, Setous, Zoleptil 100, Zoleptil 25, Zoleptil 50, Zotepin, Zotepine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Binding affinity towards human Dopamine receptor D1 | B | 7.08 | pKi | 84 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| ChEMBL | Binding affinity against dopamine receptor D1 | B | 7.54 | pKi | 29 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity towards human Dopamine receptor D2 | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| ChEMBL | Binding affinity towards human D2 dopamine receptor. | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| GtoPdb | - | - | 7.96 | pKi | 11 | nM | Ki | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Binding affinity towards human Dopamine receptor D3 | B | 7.8 | pKi | 16 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| GtoPdb | - | - | 8.19 | pKi | 6.4 | nM | Ki | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| ChEMBL | Binding affinity towards human dopamine receptor D3 | B | 8.19 | pKi | 6.4 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Binding affinity towards human dopamine-4.2 receptor | B | 7.41 | pKi | 39 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| ChEMBL | Binding affinity towards human dopamine receptor D4 | B | 7.41 | pKi | 39 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| GtoPdb | - | - | 7.41 | pKi | 39 | nM | Ki | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
| ChEMBL | Binding affinity towards human histamine H1 receptor | B | 8.47 | pKi | 3.4 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| ChEMBL | Binding affinity towards human H1 receptor | B | 9.21 | pKi | 0.62 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate | B | 6.22 | pIC50 | 602.4 | nM | IC50 | HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| ChEMBL | Binding affinity towards human muscarinic receptor | B | 6.26 | pKi | 550 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1 receptor | B | 6.48 | pKi | 330 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| GtoPdb | - | - | 6.5 | pKi | - | - | - | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity for human 5-hydroxytryptamine 2A receptor | B | 8.57 | pKi | 2.7 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| ChEMBL | Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor | B | 9.04 | pKi | 0.91 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| ChEMBL | Antagonist activity at 5HT2A receptor | F | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem (2009) 17: 7802-7815 [PMID:19836247] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptor | B | 8.54 | pKi | 2.9 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - | J Pharmacol Exp Ther (2000) 295: 226-32 [PMID:10991983] |
| 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| GtoPdb | - | - | 7.2 | pKi | - | - | - | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | - | - | - | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
| GtoPdb | - | - | 6.5 | pKi | - | - | - | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| 5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | - | - | - | Psychopharmacology (Berl.) (2005) 179: 461-9 [PMID:15821958] |
| 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] | ||||||||
| GtoPdb | - | - | 8.9 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 268: 1403-10 [PMID:7908055] |
| 5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | Psychopharmacology (Berl.) (2005) 179: 461-9 [PMID:15821958] |
| 5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 268: 1403-10 [PMID:7908055] |
| α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| GtoPdb | - | - | 8.2 | pKi | 5.7 | nM | Ki | Psychopharmacology (Berl.) (1996) 124: 57-73 [PMID:8935801] |
| NET in Human [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| GtoPdb | - | - | 7.15 | pIC50 | 71 | nM | IC50 | J Pharmacol Exp Ther (2010) 333: 772-81 [PMID:20223878] |
| SERT in Human [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| GtoPdb | - | - | 5.14 | pIC50 | 7270 | nM | IC50 | J Pharmacol Exp Ther (2010) 333: 772-81 [PMID:20223878] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
