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rondaptivon pegol   Click here for help

GtoPdb Ligand ID: 13641

Synonyms: BT-200 | BT200
Compound class: Nucleic acid
Comment: Rondaptivon pegol (BT200) belongs to the aptamer class of nucleic acid drugs/ligands. It binds to the A1 (platelet, heparin and collagen binding) domain of von Willebrand factor (vWF) [3]. Blocking interaction with receptors on platelets reduces platelet-mediated thrombogenesis [2]. Aptamer binding also prolongs the plasma half-life of factor VIII (FVIII) , which is mediated by interaction with the vWF D'/D3 domain, so offers potential in the treatment of FVIII deficiency hemophilia (hemophilia A) [1].
We have been unable to locate a full chemical SMILES for the ligand, or its HELM notation.
Classification Click here for help
Compound class Nucleic acid
Compound subclass Aptamer
Target on Willebrand factor (VWF) A1 domain
International Nonproprietary Names Click here for help
INN number INN
12620 rondaptivon pegol
Synonyms Click here for help
BT-200 | BT200
Database Links Click here for help
CAS Registry No. 2573048-75-4 (source: WHO INN record)
ChEMBL Ligand CHEMBL5314642
DrugBank Ligand DB18333
GtoPdb PubChem SID 504705460
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