RBM2-1B [Ligand Id: 8879] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2024680 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510] | ||||||||
| ChEMBL | Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | B | 4.11 | pIC50 | 77000 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
| ChEMBL | Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | B | 4.11 | pIC50 | 77000 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
| delta 4-desaturase, sphingolipid 1/Sphingolipid delta(4)-desaturase DES1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2021749] [GtoPdb: 2484] [UniProtKB: O15121] | ||||||||
| ChEMBL | Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis | B | 4.73 | pIC50 | 18800 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
| GtoPdb | Measured in a A549 cellular assay as the formation of CerC6NBD from dihydro CerC6NBD. | - | 4.74 | pIC50 | 18100 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-9 [PMID:22537678] |
| ChEMBL | Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis | B | 4.74 | pIC50 | 18100 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
