RBM2-1B [Ligand Id: 8879] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2024680
  • N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510]
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  • delta 4-desaturase, sphingolipid 1/Sphingolipid delta(4)-desaturase DES1 in Human [ChEMBL: CHEMBL2021749] [GtoPdb: 2484] [UniProtKB: O15121]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510]
ChEMBL Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis B 4.11 pIC50 77000 nM IC50 Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678]
ChEMBL Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis B 4.11 pIC50 77000 nM IC50 Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678]
delta 4-desaturase, sphingolipid 1/Sphingolipid delta(4)-desaturase DES1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2021749] [GtoPdb: 2484] [UniProtKB: O15121]
ChEMBL Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis B 4.73 pIC50 18800 nM IC50 Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678]
GtoPdb Measured in a A549 cellular assay as the formation of CerC6NBD from dihydro CerC6NBD. - 4.74 pIC50 18100 nM IC50 Bioorg Med Chem (2012) 20: 3173-9 [PMID:22537678]
ChEMBL Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis B 4.74 pIC50 18100 nM IC50 Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]