RBM2-1B [Ligand Id: 8879] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2024680
  • N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510]
There should be some charts here, you may need to enable JavaScript!
  • delta 4-desaturase, sphingolipid 1/Sphingolipid delta(4)-desaturase DES1 in Human [ChEMBL: CHEMBL2021749] [GtoPdb: 2484] [UniProtKB: O15121]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510]
ChEMBL Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis B 4.11 pIC50 77000 nM IC50 Bioorg. Med. Chem. (2012) 20: 3173-3179 [PMID:22537678]
ChEMBL Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis B 4.11 pIC50 77000 nM IC50 Bioorg. Med. Chem. (2012) 20: 3173-3179 [PMID:22537678]
delta 4-desaturase, sphingolipid 1/Sphingolipid delta(4)-desaturase DES1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2021749] [GtoPdb: 2484] [UniProtKB: O15121]
ChEMBL Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis B 4.73 pIC50 18800 nM IC50 Bioorg. Med. Chem. (2012) 20: 3173-3179 [PMID:22537678]
GtoPdb Measured in a A549 cellular assay as the formation of CerC6NBD from dihydro CerC6NBD. - 4.74 pIC50 18100 nM IC50 Bioorg Med Chem (2012) 20: 3173-9 [PMID:22537678]
ChEMBL Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis B 4.74 pIC50 18100 nM IC50 Bioorg. Med. Chem. (2012) 20: 3173-3179 [PMID:22537678]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]