RBM2-1B [Ligand Id: 8879] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2024680 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510] | ||||||||
| ChEMBL | Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | B | 4.11 | pIC50 | 77000 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
| ChEMBL | Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | B | 4.11 | pIC50 | 77000 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
| delta 4-desaturase, sphingolipid 1/Sphingolipid delta(4)-desaturase DES1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2021749] [GtoPdb: 2484] [UniProtKB: O15121] | ||||||||
| ChEMBL | Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis | B | 4.73 | pIC50 | 18800 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
| GtoPdb | Measured in a A549 cellular assay as the formation of CerC6NBD from dihydro CerC6NBD. | - | 4.74 | pIC50 | 18100 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-9 [PMID:22537678] |
| ChEMBL | Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis | B | 4.74 | pIC50 | 18100 | nM | IC50 | Bioorg Med Chem (2012) 20: 3173-3179 [PMID:22537678] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
