temelimab   Click here for help

GtoPdb Ligand ID: 11530

Synonyms: GNbAC1
Immunopharmacology Ligand
Compound class: Antibody
Comment: Temelimab (GNbAC1) is a humanised IgG4κ monoclonal antibody that binds to the extracellular domain of the human endogenous retroviral envelope protein HERV-W-Env [3-5].
SARS-CoV-2: blocking HERV-W-Env has been proposed as a mechanism to target pathologic inflammation in COVID-19 patients, based on evidence of ERV-W-Env's immunopathogenic role in immune-mediated and neurological diseases and elevated HERV-W-Env expression in T cells from SARS-CoV-2 infected individuals [1].
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10830 temelimab
Synonyms Click here for help
Database Links Click here for help
GtoPdb PubChem SID 441604902
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