temelimab   Click here for help

GtoPdb Ligand ID: 11530

Synonyms: GNbAC1
Immunopharmacology Ligand
Compound class: Antibody
Comment: Temelimab (GNbAC1) is a humanised IgG4κ monoclonal antibody that binds to the extracellular domain of the human endogenous retroviral envelope protein HERV-W-Env [3-5].
SARS-CoV-2: blocking HERV-W-Env has been proposed as a mechanism to target pathologic inflammation in COVID-19 patients, based on evidence of ERV-W-Env's immunopathogenic role in immune-mediated and neurological diseases and elevated HERV-W-Env expression in T cells from SARS-CoV-2 infected individuals [1].
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Bioactivity Comments
Positive signals of efficacy were detected in preclinical studies of temelimab (GNbAC1) in HERV-W-Env (MSRV-Env) induced experimental allergic encephalitis (EAE), an animal model of MS.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
endogenous retrovirus group W member 1, envelope Hs Antibody Binding 8.7 pKd - 4
pKd 8.7 (Kd 2.2x10-9 M) [4]