compound 6ee [PMID: 22364528] [Ligand Id: 8796] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2041169
  • egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
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  • egl-9 family hypoxia inducible factor 3/Egl nine homolog 3 in Human [ChEMBL: CHEMBL5705] [GtoPdb: 2834] [UniProtKB: Q9H6Z9]
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  • egl-9 family hypoxia inducible factor 2/Hypoxia-inducible factor prolyl hydroxylase 1 in Human [ChEMBL: CHEMBL3028] [GtoPdb: 2832] [UniProtKB: Q96KS0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
ChEMBL Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with compound for 30 mins measured after 2 hrs by time resolved fluorescence analysis B 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-59 [PMID:22364528]
egl-9 family hypoxia inducible factor 3/Egl nine homolog 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5705] [GtoPdb: 2834] [UniProtKB: Q9H6Z9]
ChEMBL Inhibition of PHD3 B 8.46 pIC50 3.5 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
GtoPdb - - 8.46 pIC50 3.5 nM IC50 J Med Chem (2012) 55: 2945-59 [PMID:22364528]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Binding affinity to human Erg B 5.09 pIC50 8100 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
egl-9 family hypoxia inducible factor 2/Hypoxia-inducible factor prolyl hydroxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3028] [GtoPdb: 2832] [UniProtKB: Q96KS0]
ChEMBL Inhibition of PHD1 B 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-59 [PMID:22364528]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]