compound 6ee [PMID: 22364528] [Ligand Id: 8796] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2041169
  • egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
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  • egl-9 family hypoxia inducible factor 3/Egl nine homolog 3 in Human [ChEMBL: CHEMBL5705] [GtoPdb: 2834] [UniProtKB: Q9H6Z9]
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  • egl-9 family hypoxia inducible factor 2/Hypoxia-inducible factor prolyl hydroxylase 1 in Human [ChEMBL: CHEMBL3028] [GtoPdb: 2832] [UniProtKB: Q96KS0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
ChEMBL Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with compound for 30 mins measured after 2 hrs by time resolved fluorescence analysis B 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-59 [PMID:22364528]
egl-9 family hypoxia inducible factor 3/Egl nine homolog 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5705] [GtoPdb: 2834] [UniProtKB: Q9H6Z9]
ChEMBL Inhibition of PHD3 B 8.46 pIC50 3.5 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
GtoPdb - - 8.46 pIC50 3.5 nM IC50 J Med Chem (2012) 55: 2945-59 [PMID:22364528]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Binding affinity to human Erg B 5.09 pIC50 8100 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
egl-9 family hypoxia inducible factor 2/Hypoxia-inducible factor prolyl hydroxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3028] [GtoPdb: 2832] [UniProtKB: Q96KS0]
ChEMBL Inhibition of PHD1 B 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-2959 [PMID:22364528]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 J Med Chem (2012) 55: 2945-59 [PMID:22364528]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]