ChEMBL ligand: CHEMBL46403 (Adeka sa 300, Barolub fta, Century 1210, Dervacid 3155, E570, Edenor htict-n, Fatty acids, hydrogenated tallow, FEMA NO. 3035, Hydrofol acid 150, Hydrogenated tallow acid, Hydrogenated tallow acid, beef, Hydrogenated tallow acids, Hydrogenated tallow fatty acids, Hyfac 410, Hyfac 420, Hyfac 421, Hyfac 422, Hystrene 7018, Kolliwax s fine, Neo-fat 18-57, Neo-fat 18-58, N-octadecanoic acid, NSC-25956, NSC-261168, Palmitostearic acid, Prifac 5905, Pristerene 4910, Pristerene 4916, Pristerene 4981, Pristerine 4989, Purified stearic acid, Stearate, Stearic acid, Stearic acid 50, Stearic acid 70, Sterene 460, Sterene 60b, Sterene 60r, Tallow acid, hydrogenated, Tallow, acids, hydrogenated, Tallow fatty acids, hydrogenated, Tallow, hydrogenated fatty acids)
Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL	Mixed type inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Dixon plot analysis	B	5.36	pKi	4400	nM	Ki	Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607]
ChEMBL	Mixed type inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Cornish-Bowden plot analysis	B	5.44	pKi	3620	nM	Ki	Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Ellman's method	B	5.12	pIC50	7500	nM	IC50	Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607]
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
ChEMBL	Binding affinity against Adipocyte lipid binding protein	B	4.1	pKd	80000	nM	Kd	J Med Chem (2002) 45: 2469-2483 [PMID:12036355]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay	B	5.96	pIC50	1100	nM	IC50	Med Chem Res (2013) 22: 3126-3133
ChEMBL	Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay	B	4.4	pEC50	40000	nM	EC50	J Med Chem (2022) 65: 1961-1978 [PMID:35089724]
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL	Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay	B	5.22	pIC50	6000	nM	IC50	Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay	B	4.52	pIC50	30000	nM	IC50	Med Chem Res (2013) 22: 3126-3133
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric method	B	5.64	pIC50	2300	nM	IC50	J Nat Prod (2020) 83: 1598-1610 [PMID:32255628]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]