stearic acid [Ligand Id: 3377] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL46403 (Purified stearic acid, Hydrogenated tallow acid, Century 1210, E570, Prifac 5905, Edenor htict-n, Hydrogenated tallow acid, beef, Sterene 60b, Neo-fat 18-58, Hyfac 422, Pristerene 4910, Hydrogenated tallow acids, Tallow acid, hydrogenated, Pristerene 4916, Hyfac 420, Stearic acid 70, Sterene 60r, Kolliwax s fine, NSC-261168, Hyfac 421, Hydrogenated tallow fatty acids, Tallow fatty acids, hydrogenated, Stearic acid 50, FEMA NO. 3035, Sterene 460, Hystrene 7018, Fatty acids, hydrogenated tallow, Tallow, acids, hydrogenated, Tallow, hydrogenated fatty acids, Pristerene 4981, Hydrofol acid 150, Dervacid 3155, Adeka sa 300, Barolub fta, NSC-25956, Stearic acid, N-octadecanoic acid, Palmitostearic acid, Stearate, Hyfac 410, Pristerine 4989, Neo-fat 18-57) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Mixed type inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Dixon plot analysis | B | 5.36 | pKi | 4400 | nM | Ki | Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607] |
| ChEMBL | Mixed type inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Cornish-Bowden plot analysis | B | 5.44 | pKi | 3620 | nM | Ki | Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Ellman's method | B | 5.12 | pIC50 | 7500 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607] |
| fatty acid binding protein 4/Fatty acid-binding protein, adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] | ||||||||
| ChEMBL | Binding affinity against Adipocyte lipid binding protein | B | 4.1 | pKd | 80000 | nM | Kd | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
| histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] | ||||||||
| ChEMBL | Inhibition of full length human recombinant HDAC11 using FAM-RHKK(tri-fluor-Ac)-NH2 as substrate by electrophoretic mobility shift assay | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2024) 276: 116634-116634 [PMID:38972077] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay | B | 5.96 | pIC50 | 1100 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| ChEMBL | Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay | B | 4.4 | pEC50 | 40000 | nM | EC50 | J Med Chem (2022) 65: 1961-1978 [PMID:35089724] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay | B | 5.22 | pIC50 | 6000 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay | B | 4.52 | pIC50 | 30000 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| protein tyrosine phosphatase non-receptor type 1/Tyrosine-protein phosphatase non-receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric method | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Nat Prod (2020) 83: 1598-1610 [PMID:32255628] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
