W-84 [Ligand Id: 362] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL31599 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| GtoPdb | - | - | 7.5 | pKd | - | - | - |
Mol Pharmacol (2003) 64: 180-90 [PMID:12815174]; J Med Chem (2004) 47: 3324-7 [PMID:15163212] |
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Mol Pharmacol (2003) 64: 180-90 [PMID:12815174] |
| ChEMBL | Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported | B | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2002) 45: 3809-3812 [PMID:12166953] |
| Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199] | ||||||||
| ChEMBL | Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart | B | 5.84 | pEC50 | 1438.8 | nM | EC50 | J Med Chem (2003) 46: 1390-1407 [PMID:12672239] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
