W-84 [Ligand Id: 362] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL31599
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • Muscarinic acetylcholine receptor M2 in Pig [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 7.5 pKd - - - Mol Pharmacol (2003) 64: 180-90 [PMID:12815174];
J Med Chem (2004) 47: 3324-7 [PMID:15163212]
GtoPdb - - 7.6 pKi - - - Mol Pharmacol (2003) 64: 180-90 [PMID:12815174]
ChEMBL Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported B 6 pEC50 1000 nM EC50 J Med Chem (2002) 45: 3809-3812 [PMID:12166953]
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
ChEMBL Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart B 5.84 pEC50 1438.8 nM EC50 J Med Chem (2003) 46: 1390-1407 [PMID:12672239]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]