astemizole [Ligand Id: 2603] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL296419 (GNF-Pf-2461, Hismanal, Astemizole, R 43,512, Pollon-eze)
  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
  • This target only has 1 pki data point
  • 4.78
1 CHEMBL296419_lig_chart_1 Adenosine A3 receptor Human
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  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
  • This target only has 1 pki data point
  • 8
2 CHEMBL296419_lig_chart_2 Alpha-1a adrenergic receptor Rat
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
  • This target only has 1 pki data point
  • 7.02
3 CHEMBL296419_lig_chart_3 Alpha-1b adrenergic receptor Rat
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • This target only has 1 pki data point
  • 6.42
4 CHEMBL296419_lig_chart_4 Alpha-1d adrenergic receptor Human
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
  • 5.74
5 CHEMBL296419_lig_chart_5 Alpha-2a adrenergic receptor Human
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 5.76
6 CHEMBL296419_lig_chart_6 Alpha-2b adrenergic receptor Human
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
  • 6.55
7 CHEMBL296419_lig_chart_7 Alpha-2c adrenergic receptor Human
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  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 1 pki data point
  • 5
8 CHEMBL296419_lig_chart_8 Beta-1 adrenergic receptor Human
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • This target only has 1 pki data point
  • 5.22
9 CHEMBL296419_lig_chart_9 Beta-3 adrenergic receptor Human
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  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
  • This target only has 1 pki data point
  • 5.34
10 CHEMBL296419_lig_chart_10 Delta opioid receptor Human
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • This target only has 1 pki data point
  • 5.7
11 CHEMBL296419_lig_chart_11 Dopamine D1 receptor Human
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • This target only has 1 pki data point
  • 5.82
12 CHEMBL296419_lig_chart_12 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 6.83
13 CHEMBL296419_lig_chart_13 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
  • 5.67
14 CHEMBL296419_lig_chart_14 Dopamine D4 receptor Human
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  • DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
  • This target only has 1 pki data point
  • 6.1
15 CHEMBL296419_lig_chart_15 Dopamine transporter Human
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 0 pki data point
  • 0
16 CHEMBL296419_lig_chart_16 Epidermal growth factor receptor erbB1 Human
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  • glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
  • This target only has 0 pki data point
  • 0
17 CHEMBL296419_lig_chart_17 Glycine receptor subunit alpha-1 Human
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18 CHEMBL296419_lig_chart_18 HERG Human
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
  • Histamine H1 receptor in Guinea pig [ChEMBL: CHEMBL3943] [UniProtKB: P31389]
  • 0
19 CHEMBL296419_lig_chart_19 Histamine H1 receptor HumanGuinea pig
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  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
  • This target only has 1 pki data point
  • 5.78
20 CHEMBL296419_lig_chart_20 Histamine H2 receptor Human
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  • H4 receptor/Histamine H4 receptor in Human [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
  • This target only has 1 pki data point
  • 5.1
21 CHEMBL296419_lig_chart_21 Histamine H4 receptor Human
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  • HLA class I histocompatibility antigen A-3 in Human [ChEMBL: CHEMBL2632] [UniProtKB: P04439]
  • This target only has 0 pki data point
  • 0
22 CHEMBL296419_lig_chart_22 HLA class I histocompatibility antigen A-3 Human
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
  • This target only has 1 pki data point
  • 5.58
23 CHEMBL296419_lig_chart_23 Kappa opioid receptor Human
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  • MC3 receptor/Melanocortin receptor 3 in Human [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
  • This target only has 1 pki data point
  • 4.87
24 CHEMBL296419_lig_chart_24 Melanocortin receptor 3 Human
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  • MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
  • This target only has 1 pki data point
  • 4.87
25 CHEMBL296419_lig_chart_25 Melanocortin receptor 4 Human
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  • MC5 receptor/Melanocortin receptor 5 in Human [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032]
  • This target only has 1 pki data point
  • 5.67
26 CHEMBL296419_lig_chart_26 Melanocortin receptor 5 Human
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  • Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
  • This target only has 0 pki data point
  • 0
27 CHEMBL296419_lig_chart_27 Multidrug and toxin extrusion protein 1 Human
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
  • This target only has 1 pki data point
  • 6.22
28 CHEMBL296419_lig_chart_28 Mu opioid receptor Human
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 1 pki data point
  • 6.59
29 CHEMBL296419_lig_chart_29 Muscarinic acetylcholine receptor M1 Human
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • This target only has 1 pki data point
  • 6.3
30 CHEMBL296419_lig_chart_30 Muscarinic acetylcholine receptor M2 Human
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • This target only has 1 pki data point
  • 6.75
31 CHEMBL296419_lig_chart_31 Muscarinic acetylcholine receptor M3 Human
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
  • 6.59
32 CHEMBL296419_lig_chart_32 Muscarinic acetylcholine receptor M4 Human
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
  • 6.3
33 CHEMBL296419_lig_chart_33 Muscarinic acetylcholine receptor M5 Human
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  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
  • This target only has 1 pki data point
  • 5.06
34 CHEMBL296419_lig_chart_34 Neurokinin 1 receptor Human
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  • NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
  • This target only has 1 pki data point
  • 6
35 CHEMBL296419_lig_chart_35 Neurokinin 2 receptor Human
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • This target only has 1 pki data point
  • 5.87
36 CHEMBL296419_lig_chart_36 Norepinephrine transporter Human
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  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
  • This target only has 0 pki data point
  • 0
37 CHEMBL296419_lig_chart_37 P-glycoprotein 1 HumanMouse
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  • ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
  • This target only has 0 pki data point
  • 0
38 CHEMBL296419_lig_chart_38 P-glycoprotein 3 Mouse
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  • Plasmodium berghei [ChEMBL: CHEMBL612653]
  • This target only has 0 pki data point
  • 0
39 CHEMBL296419_lig_chart_39 Plasmodium berghei Plasmodium berghei
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
40 CHEMBL296419_lig_chart_40 Plasmodium falciparum Plasmodium falciparum
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  • embryonic ectoderm development/Polycomb protein EED in Human [ChEMBL: CHEMBL2189117] [GtoPdb: 2487] [UniProtKB: O75530]
  • This target only has 1 pki data point
  • 4.64
41 CHEMBL296419_lig_chart_41 Polycomb protein EED Human
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
  • This target only has 0 pki data point
  • 0
42 CHEMBL296419_lig_chart_42 Receptor protein-tyrosine kinase erbB-2 Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • This target only has 1 pki data point
  • 6.36
43 CHEMBL296419_lig_chart_43 Serotonin 1a (5-HT1a) receptor Rat
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
  • This target only has 1 pki data point
  • 6.2
44 CHEMBL296419_lig_chart_44 Serotonin 1b (5-HT1b) receptor Rat
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
  • 8.25
45 CHEMBL296419_lig_chart_45 Serotonin 2a (5-HT2a) receptor Human
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
  • 8.13
46 CHEMBL296419_lig_chart_46 Serotonin 2b (5-HT2b) receptor Human
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
  • 7.03
47 CHEMBL296419_lig_chart_47 Serotonin 2c (5-HT2c) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • This target only has 1 pki data point
  • 5.82
48 CHEMBL296419_lig_chart_48 Serotonin 6 (5-HT6) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 6.15
49 CHEMBL296419_lig_chart_49 Serotonin transporter Human
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50 CHEMBL296419_lig_chart_50 Sigma intracellular receptor 2 Human
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • 5.9
51 CHEMBL296419_lig_chart_51 Sigma opioid receptor Human
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  • SST2 receptor/Somatostatin receptor 2 in Human [ChEMBL: CHEMBL1804] [GtoPdb: 356] [UniProtKB: P30874]
  • This target only has 1 pki data point
  • 5
52 CHEMBL296419_lig_chart_52 Somatostatin receptor 2 Human
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  • SST3 receptor/Somatostatin receptor 3 in Human [ChEMBL: CHEMBL2028] [GtoPdb: 357] [UniProtKB: P32745]
  • This target only has 1 pki data point
  • 5
53 CHEMBL296419_lig_chart_53 Somatostatin receptor 3 Human
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  • SST4 receptor/Somatostatin receptor 4 in Human [ChEMBL: CHEMBL1853] [GtoPdb: 358] [UniProtKB: P31391]
  • This target only has 1 pki data point
  • 5
54 CHEMBL296419_lig_chart_54 Somatostatin receptor 4 Human
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  • SST5 receptor/Somatostatin receptor 5 in Human [ChEMBL: CHEMBL1792] [GtoPdb: 359] [UniProtKB: P35346]
  • 5.39
55 CHEMBL296419_lig_chart_55 Somatostatin receptor 5 Human
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
  • This target only has 0 pki data point
  • 0
56 CHEMBL296419_lig_chart_56 Tyrosine-protein kinase FYN Human
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: