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Gene and Protein Information ![]() |
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class A G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 388 | 20p11.21 | SSTR4 | somatostatin receptor 4 | 10,35,52 |
Mouse | 7 | 385 | 2 73.44 cM | Sstr4 | somatostatin receptor 4 | 40 |
Rat | 7 | 384 | 3q41 | Sstr4 | somatostatin receptor 4 | 3 |
Previous and Unofficial Names ![]() |
SRIF2B |
Database Links ![]() |
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Specialist databases | |
GPCRdb | ssr4_human (Hs), ssr4_mouse (Mm), ssr4_rat (Rn) |
Other databases | |
Alphafold | P31391 (Hs), P49660 (Mm), P30937 (Rn) |
ChEMBL Target | CHEMBL1853 (Hs), CHEMBL4397 (Mm) |
Ensembl Gene | ENSG00000132671 (Hs), ENSMUSG00000037014 (Mm), ENSRNOG00000004641 (Rn) |
Entrez Gene | 6754 (Hs), 20608 (Mm), 25555 (Rn) |
Human Protein Atlas | ENSG00000132671 (Hs) |
KEGG Gene | hsa:6754 (Hs), mmu:20608 (Mm), rno:25555 (Rn) |
OMIM | 182454 (Hs) |
Pharos | P31391 (Hs) |
RefSeq Nucleotide | NM_001052 (Hs), NM_009219 (Mm), NM_013036 (Rn) |
RefSeq Protein | NP_001043 (Hs), NP_033245 (Mm), NP_037168 (Rn) |
UniProtKB | P31391 (Hs), P49660 (Mm), P30937 (Rn) |
Wikipedia | SSTR4 (Hs) |
Natural/Endogenous Ligands ![]() |
cortistatin-14 {Sp: Mouse, Rat} |
CST-17 {Sp: Human} |
SRIF-14 {Sp: Human, Mouse, Rat} |
SRIF-28 {Sp: Human, Mouse, Rat} |
Comments: SRIF-14 and SRIF-28 are the active fragments of precursor somatostatin. SST4 has lower affinity for SRIF-14 and SRIF-28 than the other somatostatin receptor subtypes. |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific agonist tables |
Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Antagonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
No selective antagonists available. |
Primary Transduction Mechanisms ![]() |
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Transducer | Effector/Response |
Gi/Go family | Adenylyl cyclase inhibition |
References: 2,10,29,43 |
Secondary Transduction Mechanisms ![]() |
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Transducer | Effector/Response |
Gi/Go family G protein (identity unknown) |
Potassium channel Calcium channel Other - See Comments |
Comments: Activation of K+ channels and inhibition of Ca2+ channels is via Gi/Go G-proteins. Protein tyrosine phosphatase (PTP), Na+/H+ exchanger (NHE1), MAPK cascade and PLA2 activation are via unknown G-proteins. | |
References: 2,14-15,17,20-21,23,32,38,41,46-47,53 |
Tissue Distribution ![]() |
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Expression Datasets ![]() |
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Functional Assays ![]() |
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Physiological Functions ![]() |
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Phenotypes, Alleles and Disease Models ![]() |
Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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24. Liu S, Tang C, Ho B, Ankersen M, Stidsen CE, Crider AM. (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J Med Chem, 41 (24): 4693-705. [PMID:9822540]
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26. Moneta D, Richichi C, Aliprandi M, Dournaud P, Dutar P, Billard JM, Carlo AS, Viollet C, Hannon JP, Fehlmann D, Nunn C, Hoyer D, Epelbaum J, Vezzani A. (2002) Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci, 16: 843-849. [PMID:12372020]
27. Nunn C, Rueping M, Langenegger D, Schuepbach E, Kimmerlin T, Micuch P, Hurth K, Seebach D, Hoyer D. (2003) Beta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors. Naunyn Schmiedebergs Arch Pharmacol, 367 (2): 95-103. [PMID:12595949]
28. Nunn C, Schoeffter P, Langenegger D, Hoyer D. (2003) Functional characterisation of the putative somatostatin sst2 receptor antagonist CYN 154806. Naunyn Schmiedebergs Arch Pharmacol, 367 (1): 1-9. [PMID:12616335]
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30. Patel YC, Srikant CB. (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology, 135 (6): 2814-7. [PMID:7988476]
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