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Somatostatin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST1-SST5; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [9]). Activation of these receptors produces a wide range of physiological effects throughout the body including the inhibition of secretion of many hormones. Endogenous ligands for these receptors are somatostatin-14 (SRIF-14 (SST, P61278)) and somatostatin-28 (SRIF-28 (SST, P61278)). Cortistatin-14 has also been suggested to be an endogenous ligand for somatostatin receptors [5].


SST1 receptor C Show summary » More detailed page

SST2 receptor C Show summary » More detailed page

SST3 receptor C Show summary » More detailed page

SST4 receptor C Show summary » More detailed page

SST5 receptor C Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Stefan Schulz, Corinne Bosquet, Justo P. Castaño, Zsolt Csaba, Micheal Culler, Pascal Dournaud, Jacques Epelbaum, Wasyl Feniuk, Anthony Harmar, Rebecca Hills, Leo Hofland, Daniel Hoyer, Patrick P. A. Humphrey, Hans-Jürgen Kreienkamp, Amelie Lupp, Shlomo Melmed, Wolfgang Meyerhof, Anne-Marie O'Carroll, Yogesh C. Patel, Terry Reisine, Jean-Claude Reubi, Marcus Schindler, Herbert Schmid, Agnes Schonbrunn, John E. Taylor, Giovanni Tulipano, Annamaria Vezzani, Hans-Jürgen Wester. Somatostatin receptors. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.