SN-38 [Ligand Id: 6925] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL837 (NK-012, NK 012, SN 38, 7-Ethyl-10-Hydroxy-Camptothecin, Nk012, Irinotecan related compound b, It-141, IT-141, NK012, 7-ethyl-10-hydroxycamptothecin, SN-38)
  • ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL TP_TRANSPORTER: drug resistance(Imatinib mesylate) in BCRP-expressing SaoS2 cells F 6.75 pIC50 176 nM IC50 Cancer Res. (2004) 64: 2333-2337 [PMID:15059881]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of human topoisomerase 1 B 5.26 pIC50 5500 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2018-2021 [PMID:19254843]
ChEMBL Effective concentration against DNA topoisomerase I B 6.49 pEC50 320 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 5377-5381 [PMID:15454230]
ChEMBL Effective concentration against DNA topoisomerase I B 7.15 pEC50 70 nM EC50 Bioorg. Med. Chem. Lett. (2004) 14: 5377-5381 [PMID:15454230]
DNA topoisomerase I in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2814] [GtoPdb: 2636] [UniProtKB: Q04750]
ChEMBL Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assay B 5.4 pIC50 4000 nM IC50 J. Med. Chem. (2001) 44: 1594-1602 [PMID:11334569]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]