AC1903 [Ligand Id: 10290] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1345058
  • TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
  • TRPC5/Short transient receptor potential channel 5 in Mouse [ChEMBL: CHEMBL4523481] [GtoPdb: 490] [UniProtKB: Q9QX29]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
GtoPdb Inhibition of riluzole-activated TRPC5 whole-cell current by patch-clamp recording. - 4.83 pIC50 14700 nM IC50 Science (2017) 358: 1332-1336 [PMID:29217578]
TRPC5/Short transient receptor potential channel 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523481] [GtoPdb: 490] [UniProtKB: Q9QX29]
ChEMBL Inhibition of mouse TRPC5 expressed in Flp-In-T-Rex-HEK293 cells assessed as reduction in rulizole-induced channel current by automated patch clamp method B 5.39 pIC50 4060 nM IC50 Bioorg Med Chem Lett (2019) 29: 155-159 [PMID:30538066]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]