ChEMBL ligand: CHEMBL332347 (BIBP-3226)
NPFF1 receptor/Neuropeptide FF receptor 1 in Human [ChEMBL: CHEMBL5951] [GtoPdb: 300] [UniProtKB: Q9GZQ6] There should be some charts here, you may need to enable JavaScript!
NPFF2 receptor/Neuropeptide FF receptor 2 in Human [ChEMBL: CHEMBL5952] [GtoPdb: 301] [UniProtKB: Q9Y5X5] There should be some charts here, you may need to enable JavaScript!
Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] There should be some charts here, you may need to enable JavaScript!
Y2 receptor/Neuropeptide Y receptor type 2 in Human [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] There should be some charts here, you may need to enable JavaScript!
Y4 receptor/Neuropeptide Y receptor type 4 in Human [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] There should be some charts here, you may need to enable JavaScript!
Y5 receptor/Neuropeptide Y receptor type 5 in Human [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
NPFF1 receptor/Neuropeptide FF receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5951] [GtoPdb: 300] [UniProtKB: Q9GZQ6]
ChEMBL	Competitive antagonist activity at human NPFF1 receptor expressed in COS1 cells assessed as inhibition of NPVF-induced [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	7.68	pKd	20.89	nM	Kd	J. Med. Chem. (2012) 55: 6124-6136 [PMID:22708927]
ChEMBL	Displacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assay	B	7.74	pKi	18	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Binding affinity to human NPFF1 receptor expressed in CHO cells	B	7.92	pKi	12	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
NPFF2 receptor/Neuropeptide FF receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5952] [GtoPdb: 301] [UniProtKB: Q9Y5X5]
ChEMBL	Displacement of [3H]EYF from human NPFF2 expressed in CHO cells by radioligand binding assay	B	6.6	pKi	250	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Binding affinity to human NPFF2 receptor expressed in CHO cells	B	7.08	pKi	84	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	6.63	pEC50	233	nM	EC50	J. Med. Chem. (2012) 55: 6124-6136 [PMID:22708927]
ChEMBL	Agonist activity at human NPFF2 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	6.95	pEC50	113	nM	EC50	J. Med. Chem. (2012) 55: 6124-6136 [PMID:22708927]
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL	Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay	B	8.68	pKd	2.1	nM	Kd	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
GtoPdb	-	-	8.7	pKd	2.1	nM	Kd
ChEMBL	Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells	B	5.64	pKi	2315	nM	Ki	J. Med. Chem. (1997) 40: 3712-3714 [PMID:9371234]
ChEMBL	Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane	B	7.83	pKi	14.9	nM	Ki	Bioorg. Med. Chem. Lett. (2002) 12: 379-382 [PMID:11814801]
ChEMBL	Displacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cells	B	8.29	pKi	5.1	nM	Ki	Bioorg. Med. Chem. (2011) 19: 2859-2878 [PMID:21493077]
ChEMBL	Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells	B	8.7	pKi	2	nM	Ki	J. Med. Chem. (2008) 51: 8168-8172 [PMID:19053784]
ChEMBL	Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay	B	8.82	pKi	1.5	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis	B	8.82	pKi	1.5	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells	B	8.82	pKi	1.5	nM	Ki	J. Med. Chem. (2008) 51: 8168-8172 [PMID:19053784]
ChEMBL	Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells	B	8.89	pKi	1.3	nM	Ki	Bioorg. Med. Chem. (2011) 19: 2859-2878 [PMID:21493077]
ChEMBL	Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells	B	8.89	pKi	1.3	nM	Ki	Bioorg. Med. Chem. (2008) 16: 9858-9866 [PMID:18851917]
ChEMBL	Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells	B	8.89	pKi	1.3	nM	Ki	Bioorg. Med. Chem. (2010) 18: 6292-6304 [PMID:20688523]
ChEMBL	Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells	B	8.89	pKi	1.3	nM	Ki	Bioorg. Med. Chem. (2013) 21: 6303-6322 [PMID:24074877]
ChEMBL	Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay	B	9	pKi	1	nM	Ki	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis	B	7.79	pIC50	16.22	nM	IC50	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis	B	7.93	pIC50	11.75	nM	IC50	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis	B	7.99	pIC50	10.23	nM	IC50	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting	B	8.06	pIC50	8.8	nM	IC50	J. Nat. Prod. (2009) 72: 2172-2176 [PMID:19916528]
ChEMBL	Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells	B	8.4	pIC50	3.98	nM	IC50	J. Med. Chem. (2015) 58: 8834-8849 [PMID:26466164]
ChEMBL	Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells	B	8.44	pIC50	3.63	nM	IC50	J. Med. Chem. (2008) 51: 8168-8172 [PMID:19053784]
Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
ChEMBL	Affinity for human Neuropeptide Y receptor type 2	B	5	pKi	>10000	nM	Ki	J. Med. Chem. (1997) 40: 3712-3714 [PMID:9371234]
Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391]
ChEMBL	Affinity for human Neuropeptide Y receptor type 4	B	5	pKi	>10000	nM	Ki	J. Med. Chem. (1997) 40: 3712-3714 [PMID:9371234]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 4 receptor expressed in CHO cells using Cy5-[K4]-hPP by flow cytometric analysis	B	5.3	pKi	>5000	nM	Ki	Bioorg. Med. Chem. (2013) 21: 6303-6322 [PMID:24074877]
Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761]
ChEMBL	Affinity for human Neuropeptide Y receptor type 5	B	5	pKi	>10000	nM	Ki	J. Med. Chem. (1997) 40: 3712-3714 [PMID:9371234]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]