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ChEMBL ligand: CHEMBL352396 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] | ||||||||
GtoPdb | - | - | 7.9 | pIC50 | 12.6 | nM | IC50 | Br J Pharmacol (1995) 115: 191-7 [PMID:7647976] |
ChEMBL | Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand. | B | 8.28 | pIC50 | 5.3 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 917-922 |
Sialin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630859] [GtoPdb: 1006] [UniProtKB: Q9NRA2] | ||||||||
ChEMBL | Inhibition of human recombinant-Sialin expressed in HEK293 cells assessed as reduction in [3H]Neu5Ac uptake at 30 to 300 uM incubated for 15 mins by liquid scintillation counting method | B | 4.7 | pKi | 20000 | nM | Ki | J Med Chem (2020) 63: 8231-8249 [PMID:32608236] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]