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ChEMBL ligand: CHEMBL63426 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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PAR1/Proteinase-activated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3974] [GtoPdb: 347] [UniProtKB: P25116] | ||||||||
GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | Biochem Pharmacol (2000) 60: 1425-34 [PMID:11020444] |
ChEMBL | Inhibitory activity against binding to Thrombin receptor 1 (PAR-1) | B | 7.25 | pIC50 | 56 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 2073-2078 [PMID:10450984] |
ChEMBL | Antagonist activity at PAR1 in human platelet membranes assessed as inhibition of interaction of PAR1 with [Ala-Phe(p-F)-Arg-Cha-HArg-Tyr-NH2] by Chronolog aggregometry | B | 7.25 | pIC50 | 56 | nM | IC50 | Medchemcomm (2015) 6: 510-520 [PMID:25937878] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]