SCH-79797 [Ligand Id: 10971] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL63426
  • PAR1/Proteinase-activated receptor 1 in Human [ChEMBL: CHEMBL3974] [GtoPdb: 347] [UniProtKB: P25116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAR1/Proteinase-activated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3974] [GtoPdb: 347] [UniProtKB: P25116]
GtoPdb - - 7.15 pIC50 70 nM IC50 Biochem Pharmacol (2000) 60: 1425-34 [PMID:11020444]
ChEMBL Inhibitory activity against binding to Thrombin receptor 1 (PAR-1) B 7.25 pIC50 56 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 2073-2078 [PMID:10450984]
ChEMBL Antagonist activity at PAR1 in human platelet membranes assessed as inhibition of interaction of PAR1 with [Ala-Phe(p-F)-Arg-Cha-HArg-Tyr-NH2] by Chronolog aggregometry B 7.25 pIC50 56 nM IC50 MedChemComm (2015) 6: 510-520 [PMID:25937878]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]