etanercept

Ligand id: 6789

Name: etanercept

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Classification
Compound class Antibody
Approved drug? Yes (FDA (1998), EMA (2000))
International Nonproprietary Names
INN number INN
7783 etanercept
Synonyms
Enbrel® | Rhu Tnfr:Fc | TNFR-Fc | TNR 001
Comments
Etanercept is a TNFα inhibitor. It is a dimeric recombinant protein fusing the TNF receptor 2 (TNFRSF1B) to the Fc region of the human IgG1 antibody. Etanercept is used as a disease-modifying anti-rheumatic drug (DMARD).

Biosimilars:
NameTrade nameCompanyClinical PhaseIndicationsReferences
etanercept-szzsErelziSandozApproved (2016 FDA, 2017 EMA)As per reference agent 
SB4; etanercept-ykroBrenzys; Benepali; Eticovo Samsung BioepisApproved in S Korea (2015), Canada (2016), Europe (EMA 2016), US (FDA 2019) and othersAs per reference agent[1]
 LifmiorPfizerApproved (2017 EMA)As per reference agent 
ENIA11; TuNEX; OpinerceptMycenax BiotechApproved (2018 Taiwan)Rheumatoid arthritisReuters news brief
EtaceptReumatoceptShanghai CP GoujianMarketed in Colombia as Etanar Rheumatoid arthritis 
CHS-0214 Coherus BiosciencesPh 3 (NCT02134210)Plaque psoriasis 
LBEC0101 LG Life SciencesPh 3 (NCT02357069)Rheumatoid arthritis[4-5]
Database Links
Specialist databases
IMGT/mAb-DB 216
Other databases
CAS Registry No. 185243-69-0
ChEMBL Ligand CHEMBL1201572
DrugBank Ligand DB00005
GtoPdb PubChem SID 178103395
PubChem SID 135343504
Search PubMed clinical trials etanercept
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Wikipedia Etanercept