etanercept   Click here for help

GtoPdb Ligand ID: 6789

Synonyms: Enbrel® | Rhu Tnfr:Fc | TNFR-Fc | TNR 001
Approved drug Immunopharmacology Ligand
etanercept is an approved drug (FDA (1998), EMA (2000))
Compound class: Peptide
Comment: Etanercept is a TNFα inhibitor. It is a dimeric recombinant protein fusing the TNF receptor 2 (TNFRSF1B) to the Fc region of the human IgG1 antibody. Etanercept is used as a disease-modifying anti-rheumatic drug (DMARD).

NameTrade nameCompanyClinical PhaseIndicationsReferences
etanercept-szzsErelziSandozApproved (2016 FDA, 2017 EMA)As per reference agent 
SB4; etanercept-ykroBrenzys; Benepali; Eticovo Samsung BioepisApproved in S Korea (2015), Canada (2016), Europe (EMA 2016), US (FDA 2019) and othersAs per reference agent[1]
 LifmiorPfizerApproved (2017 EMA)As per reference agent 
ENIA11; TuNEX; OpinerceptMycenax BiotechApproved (2018 Taiwan)Rheumatoid arthritisReuters news brief
YLB113NepextoMylanApproved (2020 EMA)As per reference agent 
EtaceptReumatoceptShanghai CP GoujianMarketed in Colombia as Etanar Rheumatoid arthritis 
CHS-0214 Coherus BiosciencesPh 3 (NCT02134210)Plaque psoriasis 
LBEC0101 LG Life SciencesPh 3 (NCT02357069)Rheumatoid arthritis[4-5]
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View more information in the IUPHAR Pharmacology Education Project: etanercept

Classification Click here for help
Compound class Peptide
Approved drug? Yes (FDA (1998), EMA (2000))
International Nonproprietary Names Click here for help
INN number INN
7783 etanercept
Synonyms Click here for help
Enbrel® | Rhu Tnfr:Fc | TNFR-Fc | TNR 001
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 216
Other databases
CAS Registry No. 185243-69-0
ChEMBL Ligand CHEMBL1201572
DrugBank Ligand DB00005
GtoPdb PubChem SID 178103395
PubChem SID 135343504
Search PubMed clinical trials etanercept
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Wikipedia Etanercept