Synonyms: Enbrel® | Rhu Tnfr:Fc | TNFR-Fc | TNR 001
etanercept is an approved drug (FDA (1998), EMA (2000))
Compound class:
Peptide
Comment: Etanercept is a TNFα inhibitor. It is a dimeric recombinant protein fusing the TNF receptor 2 (TNFRSF1B) to the Fc region of the human IgG1 antibody. Etanercept is used as a disease-modifying anti-rheumatic drug (DMARD).
Biosimilars:
![]() View more information in the IUPHAR Pharmacology Education Project: etanercept |
Immunopharmacology Comments |
A TNF targeting drug used to modify inflammatory disease pathology. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Juvenile idiopathic arthritis | Approved drug for severe JIA. | ||
Rheumatoid arthritis |
Disease Ontology:
DOID:7148 OMIM: 180300 |
Approved drug for severe active RA. | |
Psoriasis |
Disease Ontology:
DOID:8893 |
Approved drug for severe plaque psoriasis. | |
Ankylosing spondylitis |
Disease Ontology:
DOID:7147 |
Approved drug for AS. |