Synonyms: Enbrel® | Rhu Tnfr:Fc | TNFR-Fc | TNR 001
etanercept is an approved drug (FDA (1998), EMA (2000))
Compound class:
Peptide
Comment: Etanercept is a TNFα inhibitor. It is a dimeric recombinant protein fusing the TNF receptor 2 (TNFRSF1B) to the Fc region of the human IgG1 antibody. Etanercept is used as a disease-modifying anti-rheumatic drug (DMARD).
Biosimilars:
![]() View more information in the IUPHAR Pharmacology Education Project: etanercept |
References |
1. Emery P, Vencovský J, Sylwestrzak A, Leszczynski P, Porawska W, Baranauskaite A, Tseluyko V, Zhdan VM, Stasiuk B, Milasiene R et al.. (2017)
52-week results of the phase 3 randomized study comparing SB4 with reference etanercept in patients with active rheumatoid arthritis. Rheumatology (Oxford), 56 (12): 2093-2101. [PMID:28968793] |
2. Feldman M, Taylor P, Paleolog E, Brennan FM, Maini RN. (1998)
Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases. Transplant Proc, 30 (8): 4126-7. [PMID:9865320] |
3. Goldenberg MM. (1999)
Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther, 21 (1): 75-87; discussion 1-2. [PMID:10090426] |
4. Lee H, Chung H, Lee S, Lee H, Yang SM, Yoon SH, Cho JY, Jang IJ, Yu KS. (2017)
LBEC0101, A Proposed Etanercept Biosimilar: Pharmacokinetics, Immunogenicity, and Tolerability Profiles Compared with a Reference Biologic Product in Healthy Male Subjects. BioDrugs, 31 (4): 349-355. [PMID:28551775] |
5. Matsuno H, Tomomitsu M, Hagino A, Shin S, Lee J, Song YW. (2018)
Phase III, multicentre, double-blind, randomised, parallel-group study to evaluate the similarities between LBEC0101 and etanercept reference product in terms of efficacy and safety in patients with active rheumatoid arthritis inadequately responding to methotrexate. Ann Rheum Dis, 77 (4): 488-494. [PMID:29259050] |