ChEMBL ligand: CHEMBL21333 (Azlaire, CCN 00401, CCN-00401, ONO 1078, ONO-1078, Pranlukast, RS 411, RS-411, SB 205312, SB-205312)
Farnesoid X receptor/Bile acid receptor FXR in Human [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
Cruzipain in Trypanosoma cruzi [ChEMBL: CHEMBL3563] [UniProtKB: P25779] There should be some charts here, you may need to enable JavaScript!
CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271] Cysteinyl leukotriene receptor 1 in Guinea pig [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5] There should be some charts here, you may need to enable JavaScript!
CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75] There should be some charts here, you may need to enable JavaScript!
GPR17/Uracil nucleotide/cysteinyl leukotriene receptor in Human [ChEMBL: CHEMBL1075162] [GtoPdb: 88] [UniProtKB: Q13304] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1]
ChEMBL	Partial agonist activity at human full-length FXR expressed in human HeLa cells co-expressing pSG5-RXR measured after 24 hrs by dual-glo luciferase reporter gene assay	B	4.82	pEC50	15000	nM	EC50	J Med Chem (2019) 62: 6175-6189 [PMID:31188588]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat	F	4.39	pKi	41100	nM	Ki	Drug Metabol. Pharmacokin. (2002) 17: 23-33 [PMID:15618649]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL	Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in presence of 0.01% Triton X-100	B	4.17	pIC50	68000	nM	IC50	J. Med. Chem. (2010) 53: 4259-4265 [PMID:20426472]
ChEMBL	Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100	B	5.15	pIC50	7000	nM	IC50	J. Med. Chem. (2010) 53: 4259-4265 [PMID:20426472]
CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb	against [3H]LTD4 in human lung parenchyma	-	8.8	pKi	-	-	-	Biochem Pharmacol (2002) 63: 1537-46 [PMID:11996896]; Br J Pharmacol (1998) 123: 590-8 [PMID:9504401]
ChEMBL	Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometry	B	8.36	pIC50	4.4	nM	IC50	J Med Chem (2017) 60: 5235-5266 [PMID:28252961]
ChEMBL	Antagonist activity at human CysLT1	B	8.37	pIC50	4.3	nM	IC50	J. Med. Chem. (2015) 58: 6093-6113 [PMID:26200813]
GtoPdb	-	-	8.37	pIC50	4.3	nM	IC50	Nature (1999) 399: 789-93 [PMID:10391245]; Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]
ChEMBL	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	F	9.1	pIC50	0.8	nM	IC50	Bioorg. Med. Chem. (2010) 18: 5519-5527 [PMID:20621485]
GtoPdb	-	-	10	pIC50	0.1	nM	IC50	Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]
Cysteinyl leukotriene receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
ChEMBL	In vitro binding of Cysteinyl leukotriene receptor 1 to guinea pig lung membranes	B	9.1	pKi	0.8	nM	Ki	Bioorg. Med. Chem. Lett. (1999) 9: 2773-2778 [PMID:10509933]
ChEMBL	Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes	F	9.1	pKi	0.8	nM	Ki	Bioorg. Med. Chem. Lett. (1998) 8: 3577-3582 [PMID:9934474]
ChEMBL	Binding affinity towards Cysteinyl leukotriene D4 receptor (cysLT1) was measured by the displacement of [3H]LTD4 radioligand	B	9	pIC50	1	nM	IC50	J. Med. Chem. (1998) 41: 1439-1445 [PMID:9554877]
ChEMBL	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	B	10.36	pIC50	0.04	nM	IC50	J Med Chem (2017) 60: 5235-5266 [PMID:28252961]
CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb	against [3H]LTD4 in COS-7 cells	-	5.44	pIC50	3620	nM	IC50	J Biol Chem (2000) 275: 30531-6 [PMID:10851239]
ChEMBL	Antagonist activity at human CysLT2 expressed in HEK293T cells assessed as inhibition of LTC4-induced effect preincubated for 30 mins prior to LTC4 addition by Aequorin luminescence assay	B	5.44	pIC50	3620	nM	IC50	J. Med. Chem. (2015) 58: 6093-6113 [PMID:26200813]
GtoPdb	against LTC4 Ca2+ mobilization assay in HUVEC	-	7.1	pA2	-	-	-	Prostaglandins Other Lipid Mediat (2015) 120: 115-25 [PMID:25839425]
GPR17/Uracil nucleotide/cysteinyl leukotriene receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075162] [GtoPdb: 88] [UniProtKB: Q13304]
ChEMBL	Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by heterologous competition binding assay	B	5.39	pKi	4060	nM	Ki	ACS Med. Chem. Lett. (2014) 5: 326-330 [PMID:24900835]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]